| Primary synovial sarcoma of the lung as an incidental finding. | |
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MedLine Citation:
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PMID: 19773229 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Synovial sarcoma of the lung (SSL) is a very rare but aggressive primary lung tumor. Due to its unusual histological features, it can easily be misdiagnosed, if only small biopsies of the tumor are investigated. Here, we review two recent cases of SSL diagnosed and treated in our institution. The first case is a 37-year-old male with a round nodule in the right lower lobe; he underwent a lobectomy. Histologically, the nodule resembled a biphasic tumor. Cytogenetic analysis revealed a translocation t (X; 18), and the diagnosis of primary SSL could be established. The patient is alive and disease-free since 45 months following surgery. The second case is a 41-year-old male with a cystic lesion in the right lower lobe, removed by video-assisted thoracic surgery (VATS) segmentectomy. In the tumor tissue, spindle cell-rich and cystic structures could be found, together with epithelial elements. Because the tumor contained also a translocation t (X; 18), it could be diagnosed as monophasic SSL. The patient is alive and disease-free since 11 months. Since rare diseases of the lung may present as subtle and focal changes, complete removal of suspect pulmonary lesions is always advisable. |
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Authors:
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Stefan B Watzka; Ulrike Setinek; Helmut Prosch; Michael R M??ller |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2009-09-22 |
Journal Detail:
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Title: Interactive cardiovascular and thoracic surgery Volume: 9 ISSN: 1569-9285 ISO Abbreviation: Interact Cardiovasc Thorac Surg Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-20 Completed Date: 2010-01-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101158399 Medline TA: Interact Cardiovasc Thorac Surg Country: England |
Other Details:
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Languages: eng Pagination: 1026-8 Citation Subset: IM |
Affiliation:
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Division of Thoracic Surgery, Otto Wagner Hospital, Sanatoriumstrasse 2, 1140 Vienna, Austria. s.watzka@utanet.at |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biopsy Chromosomes, Human, Pair 18 Chromosomes, Human, X Gene Expression Regulation, Neoplastic Humans Incidental Findings* Lung Neoplasms / diagnosis*, genetics, pathology, surgery Male Pneumonectomy Sarcoma, Synovial / diagnosis*, genetics, pathology, surgery Thoracic Surgery, Video-Assisted Thoracotomy Tomography, X-Ray Computed Translocation, Genetic Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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