Document Detail

Primary squamous cell carcinoma of the liver producing parathyroid hormone-related protein.
MedLine Citation:
PMID:  11871766     Owner:  NLM     Status:  MEDLINE    
We report here an autopsy case of primary squamous cell carcinoma of the liver in a 63-year-old man who had hypercalcemia and an elevated serum level of parathyroid hormone-related protein. At autopsy, primary squamous cell carcinoma of the liver was found, without distinct preceding or associated hepatic or biliary diseases; no extrahepatic primary focus of squamous cell carcinoma was found. Bone involvement was not demonstrated, either radiologically or pathologically. Immunohistochemically, parathyroid hormone-related protein was detectable in the squamous cell carcinoma cells and it may have been responsible for the hypercalcemia. Such a case has not been reported so far in the English-language or the Japanese literature.
Takahito Saito; Kenichi Harada; Koichi Tsuneyama; Masaaki Hirano; Susumu Amaya; Motoko Sasaki; Shuichi Kaneko; Kenichi Kobayashi; Yasuni Nakanuma
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of gastroenterology     Volume:  37     ISSN:  0944-1174     ISO Abbreviation:  J. Gastroenterol.     Publication Date:  2002  
Date Detail:
Created Date:  2002-03-01     Completed Date:  2002-10-01     Revised Date:  2006-06-29    
Medline Journal Info:
Nlm Unique ID:  9430794     Medline TA:  J Gastroenterol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  138-42     Citation Subset:  IM    
Second Department of Pathology, Kanazawa University School of Medicine, Japan.
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MeSH Terms
Carcinoma, Squamous Cell / blood*,  diagnosis
Fatal Outcome
Hypercalcemia / etiology*
Liver Neoplasms / blood*,  diagnosis
Magnetic Resonance Imaging
Middle Aged
Parathyroid Hormone-Related Protein
Proteins / metabolism*
Reg. No./Substance:
0/PTHLH protein, human; 0/Parathyroid Hormone-Related Protein; 0/Proteins

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