| Primary shunt perfusion detected by colour flow Doppler imaging and its impact on liver allograft survival. | |
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MedLine Citation:
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PMID: 9193836 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Primary dysfunction (PDF) and eventual primary nonfunction (PNF) of liver allografts have been characterized by various clinical and laboratory parameters reflecting graft function, cellular integrity and extrahepatic influence following orthotopic liver transplantation (OLT). During the past 6 yr we have been able to demonstrate that this potentially devastating condition is routinely accompanied by a pathological initial perfusion pattern detected by colour flow doppler imaging (CFDI) within hours following OLT. In the majority of PDF cases (n = 30) CFDI revealed increased vascular resistance in regard to arterial blood flow to the malfunctioning graft, with a resulting 1-yr graft survival rate of 80% following the institution of early prostaglandin therapy in this group of patients. A completely different perfusion pattern was noticed by CFDI in a total of 13 cases with grossly decreased arterial resistance, resulting in an apparently supranormal arterial blood supply together with a reduced portal inflow in comparison to primarily functioning grafts. The presence of this pathologic graft perfusion was explained by the formation of arterio-portal shunts within the graft during conservation and reperfusion, leading to a 1-yr graft survival of merely 46.1%. |
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Authors:
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C Zülke; M Anthuber; H J Krämling; H Berger; K W Jauch; F W Schildberg |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical transplantation Volume: 11 ISSN: 0902-0063 ISO Abbreviation: Clin Transplant Publication Date: 1997 Jun |
Date Detail:
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Created Date: 1997-08-04 Completed Date: 1997-08-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8710240 Medline TA: Clin Transplant Country: DENMARK |
Other Details:
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Languages: eng Pagination: 163-8 Citation Subset: IM |
Affiliation:
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Department of Surgery, University Hospital, Regensburg, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arterial Occlusive Diseases
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physiopathology Arteriovenous Anastomosis / pathology, physiology Blood Flow Velocity Constriction, Pathologic / physiopathology Graft Survival* Hepatic Artery / pathology, physiology Humans Liver Circulation* Liver Transplantation / pathology, physiology, ultrasonography* Microcirculation Peripheral Vascular Diseases / physiopathology Portal Vein / pathology, physiology Prostaglandins / therapeutic use Regional Blood Flow Thrombosis / physiopathology Transplantation, Homologous Ultrasonography, Doppler, Color* Vascular Resistance Vena Cava, Inferior / pathology |
| Chemical | |
Reg. No./Substance:
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0/Prostaglandins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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