Document Detail

Primary and secondary testicular insufficiency.
MedLine Citation:
PMID:  2259544     Owner:  NLM     Status:  MEDLINE    
The possibility of testicular insufficiency is a common problem for the pediatric practitioner. Presentation varies with the severity of the defect, the developmental age achieved before onset, and the presence of associated other abnormalities. Most commonly, primary and secondary testicular insufficiency present at the time of puberty, but the presentation may be at birth or in the early neonatal period. Appropriate investigations may uncover the diagnosis at the time and allow intervention later at the appropriate age. Secondary testicular failure, although more difficult to diagnose and to differentiate from simple delay of development, offers the possibility of later development of spermatogenesis and the attainment of fertility through the use of gonadotropins or GnRH replacement programs. In primary testicular failure, because it implies an intrinsic abnormality of the functioning elements of the testis, spermatogenesis is not inducable by hormonal stimulation. Treatment of testicular failure in the neonatal period is unnecessary unless micropenis is associated. In the pubertal boy, testosterone replacement is the treatment of choice and should be initiated carefully, taking into consideration the age of the subject, his bone age, and the psychosocial circumstances. The goal of therapy is to achieve a normal progression of physical changes of puberty to physical maturity and the normal potential for sexual function.
P A Lee; L S O'Dea
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Pediatric clinics of North America     Volume:  37     ISSN:  0031-3955     ISO Abbreviation:  Pediatr. Clin. North Am.     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-01-29     Completed Date:  1991-01-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401126     Medline TA:  Pediatr Clin North Am     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1359-87     Citation Subset:  AIM; IM    
University of Pittsburgh School of Medicine, Pennsylvania.
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MeSH Terms
Hypogonadism / diagnosis,  drug therapy,  etiology,  physiopathology*
Hypothalamo-Hypophyseal System / growth & development
Infant, Newborn
Puberty, Delayed / diagnosis
Testis / growth & development,  physiopathology*
Testosterone / therapeutic use
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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