Document Detail

Primary and secondary prophylaxis of AMD by antioxidants: current risk-benefit data
MedLine Citation:
PMID:  20408079     Owner:  NLM     Status:  MEDLINE    
Supplementation of antioxidants is widely used in industrialized countries. Their popularity is based on the idea that antioxidants may avoid harmful effects caused by reactive oxygen species and in this way provide a primary and/or secondary prophylaxis against age-related diseases. AREDS was the first study that could prove a secondary prophylactic effect of antioxidants and zinc in patients with AMD. The published recommendations of the AREDS study and their transfer into practical ophthalmological care need a critical review. On the background of the original AREDS data it seems that the recommendation for supplementation includes too many AMD patients. The risks and potential side effect of the AREDS medication should always be critically considered. Currently available data do not provide evidence for an effective primary prophylaxis of AMD by the supplementation of antioxidants. Data on a positive effects of vitamin E supplementation are insignificant, but can be characterized as borderline. A paradigmatic change seems to develop in the present scientific discussion concerning the use of antioxidants, especially on the background of data from extensive meta-analyses which seem to indicate an increase of mortality risks in patients with antioxidant supplementation.
H Gerding; U Thelen
Publication Detail:
Type:  English Abstract; Journal Article; Meta-Analysis; Review     Date:  2010-04-20
Journal Detail:
Title:  Klinische Monatsbl?tter f?r Augenheilkunde     Volume:  227     ISSN:  1439-3999     ISO Abbreviation:  Klin Monbl Augenheilkd     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-21     Completed Date:  2010-05-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0014133     Medline TA:  Klin Monbl Augenheilkd     Country:  Germany    
Other Details:
Languages:  ger     Pagination:  298-301     Citation Subset:  IM    
Copyright Information:
Copyright Georg Thieme Verlag KG Stuttgart . New York.
Abteilung f?r Retinologie, Klinik Pallas, Olten, Schweiz.
Vernacular Title:
Prim?re und sekund?re Prophylaxe der AMD durch Antioxidantien: Aktuelle Datenlage zu Nutzen und Risiken.
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MeSH Terms
Antioxidants / therapeutic use*
Dietary Supplements / utilization*
Macular Degeneration / drug therapy,  epidemiology*,  prevention & control*
Risk Assessment
Treatment Outcome
Reg. No./Substance:

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