| Primary and secondary prophylaxis of AMD by antioxidants: current risk-benefit data | |
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MedLine Citation:
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PMID: 20408079 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Supplementation of antioxidants is widely used in industrialized countries. Their popularity is based on the idea that antioxidants may avoid harmful effects caused by reactive oxygen species and in this way provide a primary and/or secondary prophylaxis against age-related diseases. AREDS was the first study that could prove a secondary prophylactic effect of antioxidants and zinc in patients with AMD. The published recommendations of the AREDS study and their transfer into practical ophthalmological care need a critical review. On the background of the original AREDS data it seems that the recommendation for supplementation includes too many AMD patients. The risks and potential side effect of the AREDS medication should always be critically considered. Currently available data do not provide evidence for an effective primary prophylaxis of AMD by the supplementation of antioxidants. Data on a positive effects of vitamin E supplementation are insignificant, but can be characterized as borderline. A paradigmatic change seems to develop in the present scientific discussion concerning the use of antioxidants, especially on the background of data from extensive meta-analyses which seem to indicate an increase of mortality risks in patients with antioxidant supplementation. |
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Authors:
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H Gerding; U Thelen |
Publication Detail:
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Type: English Abstract; Journal Article; Meta-Analysis; Review Date: 2010-04-20 |
Journal Detail:
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Title: Klinische Monatsbl?tter f?r Augenheilkunde Volume: 227 ISSN: 1439-3999 ISO Abbreviation: Klin Monbl Augenheilkd Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-21 Completed Date: 2010-05-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0014133 Medline TA: Klin Monbl Augenheilkd Country: Germany |
Other Details:
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Languages: ger Pagination: 298-301 Citation Subset: IM |
Copyright Information:
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Copyright Georg Thieme Verlag KG Stuttgart . New York. |
Affiliation:
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Abteilung f?r Retinologie, Klinik Pallas, Olten, Schweiz. azol@klinik-pallas.ch |
Vernacular Title:
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Prim?re und sekund?re Prophylaxe der AMD durch Antioxidantien: Aktuelle Datenlage zu Nutzen und Risiken. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antioxidants
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therapeutic use* Dietary Supplements / utilization* Humans Macular Degeneration / drug therapy, epidemiology*, prevention & control* Prevalence Risk Assessment Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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