Document Detail

Primary and secondary prevention of cardiovascular diseases: a practical evidence-based approach.
MedLine Citation:
PMID:  19648392     Owner:  NLM     Status:  MEDLINE    
Despite the fact that we possess highly effective tools for the primary and secondary prevention of myocardial infarction and other complications of atherosclerosis, coronary heart disease remains the most common cause of death in our society. Arterial inflammation and endothelial dysfunction play central roles in the pathogenesis of atherosclerosis and adverse cardiovascular (CV) events. Therapeutic lifestyle changes in conjunction with an aggressive multidrug regimen targeted toward the normalization of the major CV risk factors will neutralize the atherogenic milieu, reduce vascular inflammation, and markedly decrease the risk of adverse CV events and need for revascularization procedures. Specific CV risk factors and optimal therapies for primary and secondary prevention are discussed.
James H O'Keefe; Maia D Carter; Carl J Lavie
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Mayo Clinic proceedings     Volume:  84     ISSN:  1942-5546     ISO Abbreviation:  Mayo Clin. Proc.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-03     Completed Date:  2009-08-21     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  0405543     Medline TA:  Mayo Clin Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  741-57     Citation Subset:  AIM; IM    
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MeSH Terms
Alcohol Drinking / adverse effects,  therapy
Cardiovascular Diseases / etiology*,  mortality,  prevention & control*
Coronary Artery Disease / complications,  therapy
Diet / adverse effects
Evidence-Based Medicine*
Fatty Acids, Omega-3 / therapeutic use
Hypertension / complications,  therapy
Life Style
Obesity / complications,  therapy
Primary Prevention / methods*
Risk Assessment
Secondary Prevention / methods*
Severity of Illness Index
Stress, Psychological
Survival Analysis
Vitamin D Deficiency / complications,  therapy
Reg. No./Substance:
0/Fatty Acids, Omega-3
Comment In:
Mayo Clin Proc. 2010 Jan;85(1):99; author reply 99-101   [PMID:  20042566 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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