Document Detail


Primary sclerosing cholangitis.
MedLine Citation:
PMID:  21822823     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Primary sclerosing cholangitis (PSC) is a chronic liver condition which may affect both intra and extrahepatic biliary tree. Etiology of PSC remains to be fully elucidated but genetic, autoimmune, inflammatory and possibly infective factors could all contribute to its development. More than two-thirds of patients are males and the most commonly associated condition is an inflammatory bowel disease which occurs in up to 70% of affected subjects. Endoscopic cholangiopancreatography (ERCP) and magnetic resonanse cholangiopancreatography (MRCP) remain a gold standard in the diagnosis of this condition. No curative treatment of PSC exists and a proportion of patients who develop liver failure or suffer from recurrent episodes of cholangitis requires liver transplantation. PSC is associated with increased risk of malignancies, in particular cholangiocarcinoma which may arise in 12% of patients. The main aim of this chapter is to review the current knowledge on pathogenesis and clinical aspects of PSC as well as its associated malignancies.
Authors:
Piotr Milkiewicz; Ewa Wunsch
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer     Volume:  185     ISSN:  0080-0015     ISO Abbreviation:  Recent Results Cancer Res.     Publication Date:  2011  
Date Detail:
Created Date:  2011-08-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0044671     Medline TA:  Recent Results Cancer Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  117-33     Citation Subset:  IM    
Affiliation:
Department of Hepatology and Liver Transplantation, M.Curie Hospital, Arkonska 4, 71-455, Szczecin, Poland, p.milkiewicz@wp.pl.
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