| Primary sclerosing cholangitis in pregnancy refractory to ursodeoxycholic acid treatment: a case report. | |
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MedLine Citation:
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PMID: 21291041 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease associated with fibrosis and inflammation of the bile ducts. Its complications include symptoms from pruritis and fatigue to dominant strictures, cholangiocarcinoma and liver failure necessitating liver transplant. Due to its predominance in young males, little is reported regarding PSC and pregnancy. CASE: We report a case of a pregnant woman with PSC whose symptoms were initially unresponsive to the traditional treatment of ursodeoxycholic acid (UDCA) early in her pregnancy but subsequently did well using high dose steroids for the duration of her pregnancy. CONCLUSION: With close management, successful pregnancy outcomes seem possible with patients with PSC, even when diagnosed multiple years prior to pregnancy, if not with UDCA, then possibly with steroid treatment. |
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Authors:
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Heidi Leftwich; Yu Ming Victor Fang; Adam Borgida; William Crombleholme |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of reproductive medicine Volume: 55 ISSN: 0024-7758 ISO Abbreviation: J Reprod Med Publication Date: 2010 Nov-Dec |
Date Detail:
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Created Date: 2011-02-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0173343 Medline TA: J Reprod Med Country: United States |
Other Details:
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Languages: eng Pagination: 517-9 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, University of Connecticut School of Medicine, Farmington, Connecticut, USA. hleftwich@resident.uchc.edu |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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