| Primary sclerosing cholangitis in genetically diverse populations listed for liver transplantation: unique clinical and human leukocyte antigen associations. | |
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MedLine Citation:
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PMID: 21031548 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Primary sclerosing cholangitis (PSC) is well characterized in European populations. We aimed to characterize clinical characteristics and human leukocyte antigen (HLA) associations in a population of European American, Hispanic, and African American PSC patients listed for liver transplantation (LT). Population-stratified demographic, clinical, and HLA data from 6767 LT registrants of the United Network for Organ Sharing who had a diagnosis of PSC (4.7% of the registrants) were compared to data from registrants with other diagnoses. Compared to European Americans and Hispanics, African Americans were significantly younger (46.6 ± 13.7, 42.3 ± 15.9, and 39.7 ± 13.1 years, respectively; P = 0.002) and were listed with a higher Model for End-Stage Liver Disease score (15.2 ± 7.5, 14.9 ± 7.6, and 18.1 ± 9.3, respectively; P = 0.001); they were also less frequently noted to have inflammatory bowel disease in comparison with European Americans (71.4% versus 60.5%, P < 0.01). In multivariate analysis, African origin was a significant factor associated with listing for LT with PSC (odds ratio with respect to European Americans = 1.325, 95% confidence interval = 1.221-1.438). HLA associations in European Americans, Hispanics, and African Americans with PSC versus alcoholic liver disease were detected for HLA-B8, HLA-DR13, and protective HLA-DR4. However, HLA-DR3, which is in linkage disequilibrium with HLA-B8, showed associations only in European Americans and Hispanics. In conclusion, African Americans with PSC who are listed for LT differ clinically from European Americans and Hispanics. The association with HLA-B8 but not HLA-DR3 in African Americans should make possible the refinement of the HLA associations in PSC. |
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Authors:
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Christopher L Bowlus; Chin-Shang Li; Tom H Karlsen; Benedicte A Lie; Carlo Selmi |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society Volume: 16 ISSN: 1527-6473 ISO Abbreviation: Liver Transpl. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-29 Completed Date: 2011-02-14 Revised Date: 2011-12-06 |
Medline Journal Info:
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Nlm Unique ID: 100909185 Medline TA: Liver Transpl Country: United States |
Other Details:
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Languages: eng Pagination: 1324-30 Citation Subset: IM |
Copyright Information:
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© 2010 AASLD. |
Affiliation:
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Division of Gastroenterology and Hepatology, University of California Davis, Davis, CA 95817, USA. clbowlus@ucdavis.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Alleles Case-Control Studies Cholangitis, Sclerosing* / complications, ethnology, genetics, immunology Colitis, Ulcerative / etiology, genetics, immunology Ethnic Groups* Female Genetic Predisposition to Disease* / ethnology Genetic Variation HLA-B8 Antigen / genetics, immunology HLA-DR Antigens / genetics, immunology Haplotypes Histocompatibility Testing Humans Inflammatory Bowel Diseases / etiology, genetics, immunology Linkage Disequilibrium Liver Diseases / complications, genetics, immunology, surgery Liver Transplantation* / immunology Logistic Models Male Middle Aged Multivariate Analysis |
| Grant Support | |
ID/Acronym/Agency:
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UL1 RR024146/RR/NCRR NIH HHS; UL1 RR024146-05/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/HLA-B8 Antigen; 0/HLA-DR Antigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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