Document Detail

Primary role of renal homografts in setting chronic blood pressure levels in rats.
MedLine Citation:
PMID:  1093748     Owner:  NLM     Status:  MEDLINE    
The genotype of homograft kidneys plays the primary role in determining chronic blood pressure levels in two strains of rats with opposite genetically controlled propensities for hyptertension. In hypertensive rats from the hypertension-prone (S) strain, a renal homograft from the same strain resulted in a slight rise in blood pressure to a level that was equivalent to that in appropriate uninephrectomized S controls. In contrast, a renal homograft from the hypertension-resistant (R) strain led to a sharp fall in blood pressure in hypertensive S recipients. Opposite results were found when the host came from the R strain: R homografts maintained the same low pressure as that seen in controls, whereas S homografts resulted in hypertension. We concluded that genetically controlled factors operating through the kidney can chronically modify the blood pressure up or down. The central role of the kidney in hypertension is thus further documented.
L K Dahl; M Heine
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation research     Volume:  36     ISSN:  0009-7330     ISO Abbreviation:  Circ. Res.     Publication Date:  1975 Jun 
Date Detail:
Created Date:  1975-09-05     Completed Date:  1975-09-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  692-6     Citation Subset:  IM    
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MeSH Terms
Blood Pressure*
Blood Urea Nitrogen
Hypertension / genetics*
Kidney Transplantation*
Rats, Inbred Strains
Sodium Chloride
Time Factors
Transplantation, Homologous
Reg. No./Substance:
7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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