Document Detail


Primary role of renal homografts in setting chronic blood pressure levels in rats.
MedLine Citation:
PMID:  1093748     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The genotype of homograft kidneys plays the primary role in determining chronic blood pressure levels in two strains of rats with opposite genetically controlled propensities for hyptertension. In hypertensive rats from the hypertension-prone (S) strain, a renal homograft from the same strain resulted in a slight rise in blood pressure to a level that was equivalent to that in appropriate uninephrectomized S controls. In contrast, a renal homograft from the hypertension-resistant (R) strain led to a sharp fall in blood pressure in hypertensive S recipients. Opposite results were found when the host came from the R strain: R homografts maintained the same low pressure as that seen in controls, whereas S homografts resulted in hypertension. We concluded that genetically controlled factors operating through the kidney can chronically modify the blood pressure up or down. The central role of the kidney in hypertension is thus further documented.
Authors:
L K Dahl; M Heine
Related Documents :
8007748 - Divalent cations in hypertension with implications to heart disease: calcium, cadmium i...
22061478 - Inhibition of metmyoglobin formation in fresh beef by pressure treatment.
2884858 - Effects of alpha 1 inhibition on renal blood flow and sympathetic nervous activity in s...
22150888 - Right-to-left atrial shunting with normal intracardiac pressures following cardiac surg...
1592908 - Oxygen transport and cardiovascular responses in skipjack tuna (katsuwonus pelamis) and...
9719148 - Cardiac remodelling in experimental renal failure--an immunohistochemical study.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation research     Volume:  36     ISSN:  0009-7330     ISO Abbreviation:  Circ. Res.     Publication Date:  1975 Jun 
Date Detail:
Created Date:  1975-09-05     Completed Date:  1975-09-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  692-6     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure*
Blood Urea Nitrogen
Diet
Genotype*
Hypertension / genetics*
Kidney Transplantation*
Rats
Rats, Inbred Strains
Sodium Chloride
Time Factors
Transplantation, Homologous
Chemical
Reg. No./Substance:
7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Regulation of stable RNA synthesis and ppGpp levels in growing cells of Escherichia coli.
Next Document:  Changes in myocardial blood flow and S-T segment elevation following coronary artery occlusion in do...