Document Detail


Primary renal carcinoid tumor with molecular abnormality characteristic of conventional renal cell neoplasms.
MedLine Citation:
PMID:  7735556     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Carcinoid tumor of the kidney is a rare neoplasm of uncertain histogenesis. Attempts to elucidate its cell of origin have been made, but there is a lack of experimental proof. We present a case of primary renal carcinoid tumor with a characteristic molecular abnormality and discuss its histogenetic implications. Histologic, immunohistochemical, and electron microscopic analyses revealed features typical of carcinoid tumor, and DNA flow cytometric analysis showed diploid pattern. Molecular genetic studies of informative WT1, p53, and 3p21 loci revealed loss of heterozygosity only at the D3F15S2 locus (3p21 telomeric). The similarity between the molecular abnormality in the present case and that in most renal cell carcinomas suggests a possible common genetic event in the genesis of these neoplasms.
Authors:
A K el-Naggar; P Troncoso; N G Ordonez
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Diagnostic molecular pathology : the American journal of surgical pathology, part B     Volume:  4     ISSN:  1052-9551     ISO Abbreviation:  Diagn. Mol. Pathol.     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-06-07     Completed Date:  1995-06-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9204924     Medline TA:  Diagn Mol Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  48-53     Citation Subset:  IM    
Affiliation:
Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
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MeSH Terms
Descriptor/Qualifier:
Base Sequence
Blotting, Southern
Carcinoid Tumor / genetics*,  ultrastructure
Carcinoma, Renal Cell / genetics,  ultrastructure
DNA Primers
Flow Cytometry
Humans
Kidney Neoplasms / genetics*,  ultrastructure
Male
Middle Aged
Molecular Sequence Data
Polymerase Chain Reaction
Chemical
Reg. No./Substance:
0/DNA Primers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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