Document Detail

Primary rat astroglial cultures can generate leukotriene B4.
MedLine Citation:
PMID:  2842377     Owner:  NLM     Status:  MEDLINE    
Astrocytes are important elements of cellular immune responses in the central nervous system. Eicosanoids exhibit immunomodulatory properties. We studied whether astroglial cells have the capacity to convert arachidonic acid via the lipoxygenase pathway to leukotriene B4 (LTB4). Calcium ionophore A23187 evoked a dose-related release of LTB4 into supernatants of primary culture rat astrocytes. This stimulatory effect was abrogated by the addition of the lipoxygenase inhibitors BW755c and nordihydroguaretic acid. Astrocyte production of the phlogistic and immunoregulatory mediator LTB4 may be one mechanism by which these cells influence immunity and inflammation in the central nervous system.
H P Hartung; K Heininger; K V Toyka
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neuroimmunology     Volume:  19     ISSN:  0165-5728     ISO Abbreviation:  J. Neuroimmunol.     Publication Date:  1988 Sep 
Date Detail:
Created Date:  1988-10-03     Completed Date:  1988-10-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8109498     Medline TA:  J Neuroimmunol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  237-43     Citation Subset:  IM    
Department of Neurology, University of Düsseldorf, F.R.G.
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MeSH Terms
Astrocytes / metabolism*
Calcimycin / pharmacology
Calcium / physiology
Cells, Cultured
Leukotriene B4 / biosynthesis*
Reg. No./Substance:
52665-69-7/Calcimycin; 71160-24-2/Leukotriene B4; 7440-70-2/Calcium

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