| Primary pulmonary hypertension in pregnancy; a role for novel vasodilators. | |
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MedLine Citation:
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PMID: 11493507 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe the case of a 28-week pregnant woman presenting with severe primary pulmonary hypertension (PPH). She had an elective Caesarean section under general anaesthesia at 32 weeks gestation. Pulmonary artery pressures (PAP) measured from a pulmonary artery catheter before anaesthesia were in excess of 100 mm Hg. Intraoperative nitric oxide was used to reduce PAP. After the delivery of a healthy infant PAP was controlled with nebulized iloprost and a prostacyclin infusion. Seven days later she was discharged from intensive care taking an oral calcium antagonist and warfarin. She developed intractable right heart failure and died 14 days after delivery. Despite increasing experience in the use of drugs to reduce PAP, the clinical course of pregnancy complicated by severe PPH is usually fatal. |
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Authors:
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L Monnery; J Nanson; G Charlton |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: British journal of anaesthesia Volume: 87 ISSN: 0007-0912 ISO Abbreviation: Br J Anaesth Publication Date: 2001 Aug |
Date Detail:
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Created Date: 2001-08-08 Completed Date: 2002-01-07 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: England |
Other Details:
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Languages: eng Pagination: 295-8 Citation Subset: IM |
Affiliation:
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Department of Anaesthesia, Dorset County Hospital, Williams Avenue, Dorchester DT1 2JY, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anesthesia, General / methods* Anesthesia, Obstetrical / methods* Cesarean Section Fatal Outcome Female Humans Hypertension, Pulmonary / drug therapy* Nitric Oxide / therapeutic use Pregnancy Pregnancy Complications / drug therapy* Vasodilator Agents / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 10102-43-9/Nitric Oxide |
| Comments/Corrections | |
Comment In:
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Br J Anaesth. 2002 Jan;88(1):151; author reply 151
[PMID:
11881877
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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