Document Detail


Primary pulmonary follicular dendritic cell neoplasm: a case report and review of the literature.
MedLine Citation:
PMID:  19391666     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Follicular dendritic cell tumor (FDCT) is an uncommon neoplasm that typically presents as a slow-growing, painless mass without systemic symptoms. Histologically, FDCT is characterized as a proliferation of spindle to ovoid cells having plump eosinophilic cytoplasm with indistinct borders and nuclei with vesicular or granular chromatin and small distinct nucleoli. The immunohistochemical profile of FDCT includes positive staining for CD21, CD23, CD35, vimentin, fascin, HLA-DR, epithelial membrane antigen, clusterin, and D2-40. Follicular dendritic cell tumor occurs primarily in lymphoid tissue; however, involvement of extranodal sites such as the tonsils, spleen, and gastrointestinal tract has been reported. Lung involvement typically represents metastatic disease with, to our knowledge, only 2 prior cases of extranodal primary FDCT of the lung reported. We report the third case of primary pulmonary FDCT arising in a 64-year-old woman.
Authors:
Krista L Denning; Peter R Olson; Richard H Maley; Veronica R Flati; Jeffrey L Myers; Jan F Silverman
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  133     ISSN:  1543-2165     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-27     Completed Date:  2009-06-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  643-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Pathology and Laboratory Medicine, Allegheny General Hospital, Pittsburgh, PA 15212, USA.
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MeSH Terms
Descriptor/Qualifier:
Dendritic Cell Sarcoma, Follicular / metabolism,  pathology*,  surgery
Diagnostic Errors
Female
Humans
Immunohistochemistry
Lung Neoplasms / metabolism,  pathology*,  surgery
Middle Aged
Pneumonectomy
Pneumonia / pathology
Radon / adverse effects
Tumor Markers, Biological / analysis
Chemical
Reg. No./Substance:
0/Tumor Markers, Biological; 10043-92-2/Radon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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