Document Detail


Primary pulmonary arterial hypertension presenting as diffuse micronodules on CT.
MedLine Citation:
PMID:  15747574     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Primary pulmonary arterial hypertension is a rare lethal disease that typically presents radiographically with enlarged central pulmonary arteries, pruning of the peripheral vasculature, and cardiomegaly but clear lung fields. Although it is a disease of unknown etiology, primary PAH has been associated with anorexigen use. We present a case of pulmonary arterial hypertension in a woman with a history of fenfluramine and phentermine use who presented with diffuse micronodules on computed tomography scan. Lung biopsy confirmed the micronodules were radiographic manifestations of extensive diffuse plexogenic arterial lesions. This report represents an unusual radiographic presentation of anorexigen related pulmonary arterial hypertension, and to our knowledge, the first case reported as presenting with diffuse micronodules on high resolution computed tomography scan.
Authors:
M R Horton; R M Tuder
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Critical reviews in computed tomography     Volume:  45     ISSN:  1548-7679     ISO Abbreviation:  Crit Rev Comput Tomogr     Publication Date:  2004  
Date Detail:
Created Date:  2005-03-07     Completed Date:  2005-05-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136418     Medline TA:  Crit Rev Comput Tomogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  335-41     Citation Subset:  IM    
Affiliation:
Johns Hopkins University School of Medicine, Division of Pulmonary and Critical Care Medicine, Department of Pathology, Baltimore, Maryland 21205, USA. mhorton2@jhmi.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Appetite Depressants / adverse effects
Asthma / complications
Drug Combinations
Female
Fenfluramine / adverse effects
Humans
Hypertension, Pulmonary / chemically induced,  complications,  radiography*
Hypertrophy
Lung / blood supply
Obesity
Phentermine / adverse effects
Pulmonary Artery / pathology,  radiography
Radiographic Image Enhancement
Tomography, X-Ray Computed*
Chemical
Reg. No./Substance:
0/Appetite Depressants; 0/Drug Combinations; 122-09-8/Phentermine; 458-24-2/Fenfluramine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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