Document Detail

Primary position upbeating nystagmus. A variety of central positional nystagmus.
MedLine Citation:
PMID:  6606479     Owner:  NLM     Status:  MEDLINE    
We report a collaborative study of 11 patients with upbeat nystagmus in the primary position of gaze. In most cases the nystagmus behaved in accordance with Alexander's Law; in 3 patients convergence enhanced the nystagmus. Lateral gaze was without effect in 7 instances. Static tilt to prone and supine positions altered the characteristics of the nystagmus in 7 patients. The effects were variable and, in one case, there was reversal of the direction of the nystagmus to downbeating. There was pathological or radiological confirmation of lesions in the pontomedullary junction (2 cases) and the pontomesencephalic junction (2 cases). The findings support previous reports that primary position upbeat nystagmus occurs predominately with intra-axial brainstem lesions. There is one report of its occurrence with an intrinsic cerebellar lesion. Modification of the amplitude of upbeat nystagmus by tilt of the head with respect to gravity in the majority of patients implies an otolith-related component in the genesis of the nystagmus.
A Fisher; M Gresty; B Chambers; P Rudge
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Brain : a journal of neurology     Volume:  106 ( Pt 4)     ISSN:  0006-8950     ISO Abbreviation:  Brain     Publication Date:  1983 Dec 
Date Detail:
Created Date:  1984-02-21     Completed Date:  1984-02-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372537     Medline TA:  Brain     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  949-64     Citation Subset:  AIM; IM    
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MeSH Terms
Brain Diseases / complications
Cerebral Infarction / complications
Cerebral Ventricle Neoplasms / complications
Ependymoma / complications
Middle Aged
Multiple Sclerosis / complications
Nystagmus, Pathologic / etiology,  physiopathology*
Pons / physiopathology
Vestibule, Labyrinth / physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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