Document Detail

Primary pleural epithelioid angiosarcoma. A case report and review of the literature.
MedLine Citation:
PMID:  20089367     Owner:  NLM     Status:  MEDLINE    
Malignant vascular tumors are uncommon sarcomas that arise from endothelial cells of small blood vessels and may affect every organ. Pleural localization is very exceptional, and only 48 cases have been reported in the English literature to date. Even if etiological factors implicated in the development of vascular sarcomas are still unclear, the strongest association with the disease was a history of chronic tuberculous pyothorax, observed only in Japanese patients, while prior radiotherapy and occupational exposure to asbestos have been reported in few Western cases. The mean age at diagnosis was 58 years, and the male to female ratio was 6:1. The overall prognosis was poor, and most of the patients died of disease soon after diagnosis. Histological features and clinical presentation often cause several problems in the differential diagnosis, particularly with mesothelioma and metastasis from poorly differentiated carcinomas. Immunohistochemistry plays an important role in identifying these rare entities, confirming the endothelial origin of the neoplasm with the expression of at least one of the vascular markers CD31, CD34, or factor VIII-related antigen. We report herein a further case of a 62-year-old man who presented with progressive dyspnea and bilateral massive hemothorax. The overall pathological and immunohistochemical features of the pleural specimens supported the diagnosis of epithelioid angiosarcoma.
Emanuele Dainese; Barbara Pozzi; Mario Milani; Giorgio Rossi; Maria Grazia Pezzotta; Giuseppe Vertemati; Paolo Tricomi; Fausto Sessa
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2010-01-20
Journal Detail:
Title:  Pathology, research and practice     Volume:  206     ISSN:  1618-0631     ISO Abbreviation:  Pathol. Res. Pract.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-31     Completed Date:  2010-08-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806109     Medline TA:  Pathol Res Pract     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  415-9     Citation Subset:  IM    
Copyright Information:
2009 Elsevier GmbH. All rights reserved.
Surgical Pathology Division, Department of Laboratory, A. Manzoni Hospital, Via dell'Eremo 9/11, 23900 Lecco, Italy.
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MeSH Terms
Diabetes Mellitus, Type 2
Diagnosis, Differential
Hemangiosarcoma / pathology*,  physiopathology,  surgery
Lung Neoplasms / pathology*,  physiopathology,  surgery
Mesothelioma / pathology
Middle Aged
Neoplasm Metastasis / pathology
Radiculopathy / complications
Tumor Markers, Biological / analysis
Reg. No./Substance:
0/Tumor Markers, Biological

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