| Primary peripheral arterial stenoses and restenoses excised by transluminal atherectomy: a histopathologic study. | |
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MedLine Citation:
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PMID: 2137149 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Atherectomy is a new therapeutic intervention for the treatment of peripheral arterial disease, and permits the controlled excision and retrieval of portions of stenosing lesions. The gross and light microscopic features of 218 peripheral arterial stenoses resected from 100 patients by atherectomy were studied. One hundred seventy of these lesions were primary stenoses and 48 were restenoses subsequent to prior angioplasty or atherectomy. Microscopically, primary stenoses were composed of atherosclerotic plaque (150 lesions), fibrous intimal thickening (15 lesions) or thrombus alone (5 lesions). Atherosclerotic plaques had a variable morphology and, in one-third of cases, were accompanied by abundant surface thrombus that probably added to the severity of stenosis. Most patients with fibrous intimal thickening or thrombus alone had typical atherosclerotic plaque removed elsewhere from within the same artery. Intimal hyperplasia, with or without underlying residual plaque, was found at 36 sites of restenosis, the remaining 12 consisting of plaque only. Intimal hyperplasia had a distinctive histologic appearance and was due to smooth muscle cell proliferation within a loosely fibrous stroma. Superimposed thrombus may have contributed to arterial narrowing in 25% of hyperplastic and 8% of atherosclerotic restenoses (p = 0.41). Pathologic examination of tissues recovered by peripheral atherectomy is an important adjunct that may provide insight into the efficacy of vascular interventions and the phenomenon of postintervention restenosis. |
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Authors:
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D E Johnson; T Hinohara; M R Selmon; L J Braden; J B Simpson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the American College of Cardiology Volume: 15 ISSN: 0735-1097 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 1990 Feb |
Date Detail:
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Created Date: 1990-03-13 Completed Date: 1990-03-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 419-25 Citation Subset: AIM; IM |
Affiliation:
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Department of Pathology, Medical College of Virginia, Richmond 23298. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Angioplasty, Balloon Arterial Occlusive Diseases / pathology, surgery*, therapy Arteries / pathology* Arteriosclerosis / pathology Constriction, Pathologic Humans Hyperplasia Middle Aged Recurrence |
| Comments/Corrections | |
Comment In:
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J Am Coll Cardiol. 1990 Feb;15(2):426-8
[PMID:
2137150
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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