Document Detail

Primary palmoplantar Kaposi's sarcoma: an unusual presentation.
MedLine Citation:
PMID:  16957440     Owner:  NLM     Status:  MEDLINE    
A 65-year-old diabetic Saudi Arabian man taking glibenclamide for 9 years presented with painful reddish patches and plaques involving the palms and soles of 6 months' duration. These lesions started as small faint purple-red macules and gradually increased in number and size. The patient did not seek any medical advice other than for these painful lesions. His medical history was insignificant. On examination, the patient had multiple, discrete, dull red-to-violaceous and tender patches and plaques of variable sizes on both palms and soles (Figure 1 and Figure 2). His mucous membranes, scalp, and nails were normal. A systemic clinical examination was unremarkable other than an amputation of the distal phalanx of the left index. Result of routine laboratory investigations including complete blood cell count, liver and renal function tests, and chest x-ray were normal. An HIV test was negative. A punch skin biopsy taken from the left palm showed acanthosis and spongiosis in the epidermis. The dermis showed a large number of dilated, medium-sized capillaries with scanty extravasated red blood cells, marked infiltration of lymphocytes and histiocytes, and a few plasma cells (Figure 3 and Figure 4). Immunohistochemistry results were positive for CD34 and CD68. Polymerase chain reaction for human herpesvirus 8 was also positive. The treatment options, including cryotherapy and intralesional chemotherapy, were discussed with the patient but, unfortunately, he did not return for follow-up.
Abdullateef A Al Zolibani; Ahmad A Al Robaee
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Skinmed     Volume:  5     ISSN:  1540-9740     ISO Abbreviation:  Skinmed     Publication Date:    2006 Sep-Oct
Date Detail:
Created Date:  2006-09-07     Completed Date:  2006-11-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101168327     Medline TA:  Skinmed     Country:  United States    
Other Details:
Languages:  eng     Pagination:  248-9     Citation Subset:  IM    
Department of Dermatology, College of Medicine, Qassim University, Buraidah, Saudi Arabia.
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MeSH Terms
Foot Diseases / pathology*
Sarcoma, Kaposi / pathology*

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