Document Detail

Primary non-Hodgkin's lymphomas of the central nervous system. Still more questions than answers in the treatment?
MedLine Citation:
PMID:  17592682     Owner:  NLM     Status:  MEDLINE    
The optimal treatment of primary non-Hodgkin"s lymphomas of the central nervous system is still under discussion. Systemic treatment is compromised by the blood-brain barrier which is impermeable to several cytostatic agents. For several years, the standard treatment has been methotrexate-based chemotherapy followed by CNS-radiotherapy. However, this combination therapy may be complicated by later neurotoxicity. Intensive chemotherapy followed by autologous stem-cell transplantation is a new promising treatment approach without increased CNS-toxicity.
Per Boye Hansen; Morten Krogh Jensen
Publication Detail:
Type:  English Abstract; Journal Article; Review    
Journal Detail:
Title:  Ugeskrift for laeger     Volume:  169     ISSN:  1603-6824     ISO Abbreviation:  Ugeskr. Laeg.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-26     Completed Date:  2007-07-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0141730     Medline TA:  Ugeskr Laeger     Country:  Denmark    
Other Details:
Languages:  dan     Pagination:  2187-9     Citation Subset:  IM    
Herlev Hospital, Medicinsk Haematologisk Afdeling L, Herlev.
Vernacular Title:
Primaere non-Hodgkin-lymfomer i centralnervesystemet. Stadig flere spørgsmål end svar i behandlingen?
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MeSH Terms
Antineoplastic Agents / therapeutic use
Brain Neoplasms / drug therapy,  radiotherapy,  therapy*
Combined Modality Therapy
Lymphoma, B-Cell / drug therapy,  radiotherapy,  therapy
Lymphoma, Non-Hodgkin / drug therapy,  radiotherapy,  therapy*
Lymphoma, T-Cell / drug therapy,  radiotherapy,  therapy
Stem Cell Transplantation
Treatment Outcome
Reg. No./Substance:
0/Antineoplastic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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