Document Detail

Primary meningeal rhabdomyosarcoma.
MedLine Citation:
PMID:  21772793     Owner:  NLM     Status:  In-Data-Review    
Primary meningeal rhabdomyosarcoma is a rare primary brain malignancy, with scant case reports. While most reports of primary intracranial rhabdomyosarcoma occur in pediatric patients, a handful of cases in adult patients have been reported in the medical literature. We report the case of a 44-year-old male who developed primary meningeal rhabdomyosarcoma. After developing episodes of right lower extremity weakness, word finding difficulty, and headaches, a brain magnetic resonance imaging (MRI) demonstrated a vertex lesion with radiographic appearance of a meningeal-derived tumor. Subtotal surgical resection was performed due to sagittal sinus invasion and initial pathology was interpreted as an anaplastic meningioma. Re-review of pathology demonstrated rhabdomyosarcoma negative for alveolar translocation t(2;13). Staging studies revealed no evidence of disseminated disease. He was treated with stereotactic radiotherapy with concurrent temozolamide to be followed by vincristine, actinomycin-D, and cyclophosphamide (VAC) systemic therapy.
Manisha Palta; Richard F Riedel; James J Vredenburgh; Thomas J Cummings; Scott Green; Zheng Chang; John P Kirkpatrick
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Publication Detail:
Type:  Journal Article     Date:  2011-06-23
Journal Detail:
Title:  Sarcoma     Volume:  2011     ISSN:  1369-1643     ISO Abbreviation:  Sarcoma     Publication Date:  2011  
Date Detail:
Created Date:  2011-07-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9709257     Medline TA:  Sarcoma     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  312802     Citation Subset:  -    
Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA.
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