Document Detail

Primary meningeal lymphoma presenting solely with blindness: a report of an autopsy case.
MedLine Citation:
PMID:  8762816     Owner:  NLM     Status:  MEDLINE    
A 64-year-old woman was admitted because of progressive paraplegia. She had a history of unexplained blindness which had developed gradually 1 year earlier. The contrast-enhanced CT showed a small mass at the sella turcica. The funduscopy showed merely atrophic discs. The lumbar puncture revealed marked pleocytosis (cell count: 10.4 x 10(9)/l) and a diagnosis of meningeal lymphoma was made by the cytology of the cerebrospinal fluid. No lymphomatous lesions were detected outside of the central nervous system (CNS) and the patient received whole brain irradiation together with intrathecal chemotherapy. However, there was no improvement in vision or other neurological activities. Eventually the patient died of interstitial pneumonia 2 months after admission. The autopsy revealed a residual B-cell lymphoma existing only in the leptomeninges of medulla oblongata. The optic nerves were atrophic macroscopically and massive gliosis was seen microscopically. In addition, cytomegalovirus infection was observed in the lungs and adrenal glands but not in the CNS. This patient must have had a primary meningeal lymphoma. The mechanism of the visual loss of this patient is discussed.
C Sakai; T Takagi; S Wakatsuki
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  International journal of hematology     Volume:  63     ISSN:  0925-5710     ISO Abbreviation:  Int. J. Hematol.     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-09-19     Completed Date:  1996-09-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9111627     Medline TA:  Int J Hematol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  325-9     Citation Subset:  IM    
Division of Hematology and Chemotherapy, Chiba Cancer Center Hospital, Japan.
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MeSH Terms
Blindness / etiology*
Combined Modality Therapy
Fatal Outcome
Gliosis / etiology,  pathology
Lung Diseases, Interstitial / etiology
Lymphoma, B-Cell / complications*,  drug therapy,  pathology,  radiotherapy
Medulla Oblongata*
Meningeal Neoplasms / complications*,  drug therapy,  pathology,  radiotherapy
Middle Aged
Optic Nerve / pathology*
Paraplegia / etiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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