Document Detail

Primary mediastinal (thymic) large B cell lymphoma with aberrant expression of CD3: a case report with review of the literature.
MedLine Citation:
PMID:  20131102     Owner:  NLM     Status:  MEDLINE    
We report the first case of primary mediastinal large B cell lymphoma (PMBL) with aberrant expression of CD3. PMBL is a subtype of diffuse large B cell lymphoma (DLBCL) and usually presents with bulky mediastinal lesions. Lineage ambiguity/infidelity is uncommon in DLBCL but has been described in sporadic case reports/series. A literature search identifies 13 additional cases of DLBCL expressing CD3, with the majority displaying cytoplasmic expression. Of the 14 total cases, 6 are pyothorax-associated lymphoma, 4 are conventional DLBCL, 2 are plasmablastic lymphoma, one is primary effusion lymphoma and one is PMBL. Two cases show genotypic ambiguity/infidelity with dual clonal IG and TCR gene rearrangements in addition to ambiguous immunophenotypes. Of the 13 cases tested for EBV status, 11 are positive, suggesting an important role of EBV in promoting lineage ambiguity/infidelity. A low threshold for testing EBV status is advocated in DLBCL with phenotypic ambiguity along with panels of immunohistochemical and molecular studies.
Endi Wang; Maggie Stoecker
Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2010-02-04
Journal Detail:
Title:  International journal of hematology     Volume:  91     ISSN:  1865-3774     ISO Abbreviation:  Int. J. Hematol.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-05     Completed Date:  2010-06-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111627     Medline TA:  Int J Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  509-15     Citation Subset:  IM    
Department of Pathology, Duke University Medical Center, DUMC Box 3712, M-345 Davison Bldg Green Zone, Duke Hospital South, Durham, NC 27710, USA.
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MeSH Terms
Antigens, CD3 / metabolism*
Lymphoma, Large B-Cell, Diffuse / metabolism*,  pathology*,  radiography
Mediastinal Neoplasms / metabolism*,  pathology*,  radiography
Thymus Neoplasms / metabolism,  pathology,  radiography
Reg. No./Substance:
0/Antigens, CD3

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