Document Detail

Primary malignant mesothelioma developed in liver.
MedLine Citation:
PMID:  18705333     Owner:  NLM     Status:  MEDLINE    
The following reports a rare case of primary localized malignant mesothelioma of the liver. A 53-year-old man with no history of exposure to asbestos was admitted to our department for evaluation of incidentally detected liver mass. Computed tomography and hepatic angiogram showed a tumor at the dome of the liver, which was fed mainly through the inferior phrenic artery. The mass was resected, including a portion of the diaphragm. Microscopically, the tumor was composed of cord-like or trabecular arrangements of epithelioid cells having abundant eosinophilic cytoplasm and prominent nucleoli. Immunohistochemically, the tumor cells were strongly positive for calretinin and cytokeratin 5 and negative for hepatocyte markers. These findings were consistent with our diagnosis of epithelioid mesothelioma. A local recurrence was noted 15 months after surgery, which was treated by radiofrequency ablation. At 23 months after initial surgery, locally recurrent masses with direct invasion of the diaphragm and a solitary intrahepatic metastasis were noted, which was treated by partial excision of the diaphragm with intraoperative RFA after transarterial chemoembolization.
Dong-Sik Kim; Sung-Gyu Lee; Sun-Young Jun; Kyoung Won Kim; Tae-Yong Ha; Keon-Kuk Kim
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  55     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:    2008 May-Jun
Date Detail:
Created Date:  2008-08-18     Completed Date:  2008-12-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  1081-4     Citation Subset:  IM    
Division of Transplantation and Hepatobiliary Surgery, Department of Surgery, University of Cincinnati, Cincinnati, OH, USA.
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MeSH Terms
Calcium-Binding Protein, Vitamin D-Dependent / analysis
Catheter Ablation
Follow-Up Studies
Keratins / analysis
Liver Neoplasms / blood supply,  pathology,  radiography,  surgery*
Mesothelioma / blood supply,  pathology,  radiography,  surgery*
Middle Aged
Neoplasm Recurrence, Local / surgery
Tomography, X-Ray Computed
Tumor Markers, Biological / analysis
Reg. No./Substance:
0/Calcium-Binding Protein, Vitamin D-Dependent; 0/Tumor Markers, Biological; 0/calretinin; 68238-35-7/Keratins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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