| Primary malignant meningeal melanomatosis: a clinical, radiological and pathologic case study. | |
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MedLine Citation:
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PMID: 22141290 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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A 40 year-old woman with subacute headache and visual impairment was admitted. Neurological examination revealed meningismus, diminished visual acuity, bilateral sixth cranial nerve palsy, and papillary edema. Dermatologic examination was normal. The brain CT scan showed hydrocephalus and hyperdense edging around fissures and sulci. The CSF study showed an increased protein level, with persistently negative microbiologic and cytological studies. Prior to Gd-DPTA injection, the brain T1-WI MRI revealed leptomeningeal hyperintensity. A dark subpial substance became evident at cerebral biopsy. The histopatological diagnosis was diffuse leptomeningeal melanomatosis. This case report highlights the diagnostic value of the brain MRI findings in primary leptomeningeal melanomatosis, a rare pathologic condition diagnosed in most published cases only after necropsy. Meningeal T1-WI hyperintensity prior to contrast injection is not caused by sarcoidosis or meningeal carcinomatosis, lymphomatosis or gliomatosis. |
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Authors:
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Manuel Arias; Miguel Alberte-Woodward; Susana Arias; Dolores Dapena; Angel Prieto; José Manuel Suárez-Peñaranda |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta neurologica Belgica Volume: 111 ISSN: 0300-9009 ISO Abbreviation: Acta Neurol Belg Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-12-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0247035 Medline TA: Acta Neurol Belg Country: Italy |
Other Details:
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Languages: eng Pagination: 228-31 Citation Subset: IM |
Affiliation:
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Services of Neurology, Complexo Hospitalario Universitario, Santiago de Compostela, Spain. mariasg@meditex.es |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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