Document Detail

Primary malignant mediastinal tumors.
MedLine Citation:
PMID:  6095777     Owner:  NLM     Status:  MEDLINE    
Thirty-eight patients with primary malignant mediastinal tumors of all cell types are the basis for this review. Eleven of these patients had germ cell tumors. Five germ cell tumors were seminomas, two were malignant teratomas, and two were endodermal sinus tumors. Mean survival for all patients with germ cell tumors was 3.3 years. Eight children had surgical excision of mediastinal neuroblastomas, and all but 1 are alive for a mean survival of 6.7 years. Seven patients had lymphoproliferative disorders; 6 of these patients had nodular sclerosing Hodgkin's disease, and 1 had lymphoblastic (thymic) lymphoma. Mean survival was 5.1 years. There were five carcinomas of various cell types and one angiopericytoma. None of the patients with these lesions survived more than 2 years. Four patients had thymoma with an average survival of 3.7 years. Two patients had carcinoid tumors of thymic origin; neither survived more than 1 year. In 1972, we reported 5-year disease-free survival of 26% in a series of patients with primary mediastinal tumors. Our experience since 1970 shows current survival of 47.3% and 5-year disease-free survival of 34.2%. We use combined methods of therapy, including aggressive surgical resection, combination chemotherapy, and often mediastinal irradiation for most types of mediastinal tumors. Primary mediastinal malignancies should be treated aggressively using a multidisciplinary approach, since many of these tumors are curable.
R B Adkins; M D Maples; J D Hainsworth
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  38     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1985-01-15     Completed Date:  1985-01-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  648-59     Citation Subset:  AIM; IM    
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MeSH Terms
Carcinoid Tumor / therapy
Carcinoma / therapy
Child, Preschool
Combined Modality Therapy
Hemangiopericytoma / radiotherapy
Infant, Newborn
Lymphoma / therapy
Mediastinal Neoplasms / diagnosis,  pathology,  therapy*
Middle Aged
Neoplasms, Germ Cell and Embryonal / diagnosis,  therapy
Neuroblastoma / therapy
Thymoma / therapy
Thymus Neoplasms / therapy

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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