Document Detail

Primary macular amyloidosis: an ultrastructural approach to diagnosis.
MedLine Citation:
PMID:  10582265     Owner:  NLM     Status:  MEDLINE    
Seven cases of primary macular amyloidosis were studied on skin biopsies. The Congo red stain was positive only in three cases, whereas the ultrastructural observation allowed for the detection of amyloid deposits in all biopsies. Fibrillary degeneration of basal keratynocytes was occasionally observed, and regressive changes of keratynocytes and dermal nerve bundles presumably related to the intensity of the scratch trauma were detected in one case. In six biopsies mast cell profiles exhibiting various degrees of degranulation were detected in the dermis. Melanosome aggregates were also observed consistently in dermal macrophages and occasionally in Schwann cells. A variable degree of structural alteration was observed in dermal unmyelinated nerve fibers. Even if the intimate mechanism of amyloid deposition was not explained by the ultrastructural study, this approach is a useful instrument in the differential diagnosis of cutaneous macular hyperpigmented lesions.
C Schepis; M Siragusa; M E Gagliardi; V Torre; R Cicciarello; F Albiero; V Cavallari
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Ultrastructural pathology     Volume:  23     ISSN:  0191-3123     ISO Abbreviation:  Ultrastruct Pathol     Publication Date:    1999 Sep-Oct
Date Detail:
Created Date:  1999-12-15     Completed Date:  1999-12-15     Revised Date:  2009-06-26    
Medline Journal Info:
Nlm Unique ID:  8002867     Medline TA:  Ultrastruct Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  279-84     Citation Subset:  IM    
Unit of Dermatology, Oasi Institute (IRCCS), Troina, Italy.
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MeSH Terms
Amyloid / metabolism,  ultrastructure*
Amyloidosis / diagnosis*,  metabolism
Coloring Agents
Congo Red
Middle Aged
Skin / metabolism,  ultrastructure*
Skin Diseases / diagnosis*,  metabolism
Staining and Labeling
Reg. No./Substance:
0/Amyloid; 0/Coloring Agents; 573-58-0/Congo Red

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