Document Detail


Primary lung involvement in Waldenström's macroglobulinaemia: report of two cases and review of the literature.
MedLine Citation:
PMID:  11408711     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pulmonary involvement in Waldenström's macroglobulinaemia (WM) occurs in 3-5% of cases, but lung involvement without bone marrow infiltration is extremely rare. We report 2 patients who presented with bilateral consolidations on chest X-ray and non-specific symptoms and were treated for a long period of time for pulmonary infections until the diagnosis was made by open lung biopsy. Both patients presented high monoclonal IgM in the serum and one also had blood lymphoplasmacytosis. Trephine bone biopsy and bone marrow smears were normal and there was no other site of involvement. Along with the presentation of our patients, we review the literature, discuss some of the possible underlying mechanisms and raise the attention of clinicians to this rare manifestation of the disease.
Authors:
M C Kyrtsonis; M K Angelopoulou; F N Kontopidou; M P Siakantaris; M N Dimopoulou; F Mitropoulos; A Kalovidouris; G A Vaiopoulos; G A Pangalis
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Acta haematologica     Volume:  105     ISSN:  0001-5792     ISO Abbreviation:  Acta Haematol.     Publication Date:  2001  
Date Detail:
Created Date:  2001-06-15     Completed Date:  2001-07-12     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0141053     Medline TA:  Acta Haematol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  92-6     Citation Subset:  IM    
Copyright Information:
Copyright 2001 S. Karger AG, Basel.
Affiliation:
Hematology Section, First Department of Internal Medicine, National and Kapodistrian University, School of Medicine, Laikon General Hospital, Athens, Greece.
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MeSH Terms
Descriptor/Qualifier:
Aged
Humans
Immunoglobulin M / blood
Lung Neoplasms / diagnosis,  drug therapy,  radiography*
Lymphoma / diagnosis,  drug therapy,  radiography
Male
Waldenstrom Macroglobulinemia / diagnosis*,  drug therapy,  pathology
Chemical
Reg. No./Substance:
0/Immunoglobulin M

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