| Primary lung cancer. A controlled study of preoperative and postoperative levels of circulating immune complexes. | |
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MedLine Citation:
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PMID: 3258788 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Three complement-dependent and one rheumatoid factor-dependent immune complex assays were used to analyze the sera taken before surgery from 70 unselected and previously untreated lung cancer patients, from 30 of them after surgery, and from 31 healthy controls. Plasma levels of complement split product C3d were also analyzed. The levels of circulating immune complexes (cIC) and C3d were essentially the same in samples taken from lung cancer patients before surgery and from healthy controls. By the four immune complex assays, increased levels were found in 0 to 10% of the preoperative lung cancer patients compared to 3% of the healthy controls (not significant). The postsurgical tumor, lymph node, metastasis (pTNM) stage of the lung cancer was not reflected in the levels of cIC or C3d. Paired comparisons of the cIC and C3d levels before and after surgery did not show significant differences. Thus, we found no evidence for the occurrence of cancer-related cIC in lung cancer patients. |
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Authors:
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A Bukh; M T Aguado; H H Kimose; C Mouritzen; N P Møoller |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cancer Volume: 61 ISSN: 0008-543X ISO Abbreviation: Cancer Publication Date: 1988 May |
Date Detail:
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Created Date: 1988-06-07 Completed Date: 1988-06-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374236 Medline TA: Cancer Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2033-41 Citation Subset: AIM; IM |
Affiliation:
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Institute of Medical Microbiology, University of Aarhus, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antibodies, Neoplasm / analysis Antigen-Antibody Complex / analysis* Blood Specimen Collection Complement C3 / analysis Complement C3d Enzyme-Linked Immunosorbent Assay Female Humans Immunoelectrophoresis Lung Neoplasms / immunology*, pathology, surgery Male Middle Aged Postoperative Period Radioimmunoassay Rheumatoid Factor / analysis |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Neoplasm; 0/Antigen-Antibody Complex; 0/Complement C3; 80295-45-0/Complement C3d; 9009-79-4/Rheumatoid Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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