Document Detail

Primary liver cancer in genetic hemochromatosis: a clinical, pathological, and pathogenetic study of 54 cases.
MedLine Citation:
PMID:  8419246     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although liver cancer arises frequently in the course of genetic hemochromatosis (GH), it has not been previously studied in a large series of patients with well-defined GH. METHODS: The bioclinical and pathological data from 1 cholangiocarcinoma and 53 hepatocellular carcinomas (HCCs) complicating GH in 32 untreated and 22 de-ironed patients are reported. RESULTS: This study (1) adds three new well-documented cases of HCC in noncirrhotic but only fibrotic hemochromatotic liver, (2) shows the high prevalence (83%) of proliferative and often dysplastic (70%) iron-free foci in the nontumorous liver of untreated patients, and (3) emphasizes the significant increase of cirrhosis (81% vs. 28%) and of associated noniron-related risk factors, mainly chronic alcoholism (48% vs. 25%) and tobacco smoking (50% vs. 18%) in patients with HCC compared with matched hemochromatotic patients without HCC. CONCLUSIONS: These data (1) suggest that iron-free foci may be markers of an early stage of HCC in GH and (2) supply the basis for defining a cost-effective policy for the screening of HCC in GH patients.
Y M Deugnier; D Guyader; L Crantock; J M Lopez; B Turlin; J Yaouanq; H Jouanolle; J P Campion; B Launois; J W Halliday
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gastroenterology     Volume:  104     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-02-08     Completed Date:  1993-02-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  228-34     Citation Subset:  AIM; IM    
Clinique des Maladies du Foie and INSERM U 49, CHRU Pontchaillou, Rennes, France.
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MeSH Terms
Hemochromatosis / blood,  complications,  genetics*
Iron / blood
Liver Neoplasms / complications*,  etiology,  pathology
Middle Aged
Risk Factors
Reg. No./Substance:

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