Document Detail

Primary leptomeningeal melanoma: an ultrastructural study.
MedLine Citation:
PMID:  630534     Owner:  NLM     Status:  MEDLINE    
A primary leptomeningeal melanoma in a 19-year-old white women has been shown by electron microscopy to contain light and dark cells. The light cells fill the subarachnoid space, contain mature melanosomes and exhibit intracytoplasmic fine fibrils. The dark cells are found within the collagen network of pia-arachnoid. They possess a small rim of ribosomal-rich cytoplasms, occasional premelanosomes and no intracytoplasmic fibrils. The tumor cells appear to arise from these dark activated melanoblasts in the pia-arachnoid and proliferate into more differentiated light cells. A similar pattern of two types of cells has not been described in primary CNS melanomas. The possibility of differentiation from cutaneous melanoma is discussed.
S W Silbert; K R Smith; S Horenstein
Related Documents :
21355564 - Steering cell migration using microarray amplification of natural directional persistence.
18424844 - Characterization of a biphasic neoplasm in a madagascar tree boa (sanzinia madagascarie...
9085154 - Clear-cell atypical fibroxanthoma: an uncommon histopathologic variant of atypical fibr...
10343474 - Cerebriform intradermal nevus: a case of scalp expansion on the galea.
21818404 - Fibroblast growth factor-2 primes human mesenchymal stem cells for enhanced chondrogene...
25367414 - Effect of amphiphilic pcl-peg nano-micelles on hepg2 cell migration.
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cancer     Volume:  41     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1978 Feb 
Date Detail:
Created Date:  1978-05-17     Completed Date:  1978-05-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  519-27     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Arachnoid / ultrastructure
Cell Differentiation
Cytoplasmic Granules / ultrastructure
Melanocytes / ultrastructure
Melanoma / ultrastructure*
Meningeal Neoplasms / ultrastructure*
Organoids / ultrastructure
Pia Mater / ultrastructure

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Computed tomographic scanning in patients with lymphoma.
Next Document:  Triiodothyronine-secreting (toxic) adenoma of the thyroid gland: light and electron microscopic char...