Document Detail

Primary leptomeningeal melanoma: an ultrastructural study.
MedLine Citation:
PMID:  630534     Owner:  NLM     Status:  MEDLINE    
A primary leptomeningeal melanoma in a 19-year-old white women has been shown by electron microscopy to contain light and dark cells. The light cells fill the subarachnoid space, contain mature melanosomes and exhibit intracytoplasmic fine fibrils. The dark cells are found within the collagen network of pia-arachnoid. They possess a small rim of ribosomal-rich cytoplasms, occasional premelanosomes and no intracytoplasmic fibrils. The tumor cells appear to arise from these dark activated melanoblasts in the pia-arachnoid and proliferate into more differentiated light cells. A similar pattern of two types of cells has not been described in primary CNS melanomas. The possibility of differentiation from cutaneous melanoma is discussed.
S W Silbert; K R Smith; S Horenstein
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cancer     Volume:  41     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1978 Feb 
Date Detail:
Created Date:  1978-05-17     Completed Date:  1978-05-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  519-27     Citation Subset:  AIM; IM    
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MeSH Terms
Arachnoid / ultrastructure
Cell Differentiation
Cytoplasmic Granules / ultrastructure
Melanocytes / ultrastructure
Melanoma / ultrastructure*
Meningeal Neoplasms / ultrastructure*
Organoids / ultrastructure
Pia Mater / ultrastructure

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