| Primary leiomyosarcoma of extragnathic bone: clinicopathologic features and reevaluation of prognosis. | |
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MedLine Citation:
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PMID: 19722754 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: Leiomyosarcoma most commonly involves the female genital tract and occasionally arises within the retroperitoneum, abdominal cavity, or the soft tissues of the extremity. Presentation as a primary bone tumor is extraordinarily uncommon, potentially leading to misdiagnosis. The prognosis is traditionally thought to be dismal. However, this conclusion is largely based on individual case reports and small series, in some of which the pathologic diagnosis is not well documented. OBJECTIVE: To review the clinicopathologic features of well-established cases of primary skeletal leiomyosarcoma and reevaluate the prognostic implications thereof. DATA SOURCES: A National Center for Biotechnology Information PubMed search of the English language literature identified 104 authenticated cases of primary leiomyosarcoma of extragnathic bone. An additional 3 cases are reported and illustrated herein. CONCLUSIONS: Approximately half of all patients with primary skeletal leiomyosarcoma either presented with metastatic disease or developed metastases within 1 year of diagnosis. The 5-year overall and disease-free survival rates were 59% and 41%, respectively, comparable to that of other skeletal sarcomas. As for other bone and soft tissue sarcomas, high histologic grade and tumor stage are predictive of poor outcome. |
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Authors:
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Muyibat A Adelani; Stephen J Schultenover; Ginger E Holt; Justin M M Cates |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Archives of pathology & laboratory medicine Volume: 133 ISSN: 1543-2165 ISO Abbreviation: Arch. Pathol. Lab. Med. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-09-02 Completed Date: 2009-09-22 Revised Date: 2010-11-12 |
Medline Journal Info:
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Nlm Unique ID: 7607091 Medline TA: Arch Pathol Lab Med Country: United States |
Other Details:
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Languages: eng Pagination: 1448-56 Citation Subset: AIM; IM |
Affiliation:
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Department of Orthopaedic Surgery, Washington University in St Louis, St Louis, Missouri, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Bone Neoplasms / mortality, pathology*, therapy Combined Modality Therapy Databases, Bibliographic Disease-Free Survival Female Humans Leiomyosarcoma / mortality, pathology*, therapy Male Middle Aged Survival Rate |
| Comments/Corrections | |
Comment In:
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Arch Pathol Lab Med. 2010 Nov;134(11):1583-4
[PMID:
21043809
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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