Document Detail

Primary lateral sclerosis.
MedLine Citation:
PMID:  17212349     Owner:  NLM     Status:  MEDLINE    
The spectrum of motor neuron diseases ranges from disorders that clinically are limited to lower motor neurons to those that exclusively affect upper motor neurons. Primary lateral sclerosis (PLS) is the designation for the syndrome of progressive upper motor neuron dysfunction when no other etiology is identified. Distinction between PLS and the more common amyotrophic lateral sclerosis (ALS) relies primarily on recognition of their symptoms and signs, as well as on ancillary, although non-specific, laboratory data. In this review, we survey the history of PLS from the initial descriptions to the present. We discuss the role of laboratory, electrodiagnostic, and imaging studies in excluding other diagnoses; the findings from major case series of PLS patients; and proposed diagnostic criteria. Consistent differences are evident in patients classified as PLS compared to those with ALS, indicating that, despite its limitations, this clinical designation retains important utility.
Mike A Singer; Jeffrey M Statland; Gil I Wolfe; Richard J Barohn
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Muscle & nerve     Volume:  35     ISSN:  0148-639X     ISO Abbreviation:  Muscle Nerve     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-15     Completed Date:  2007-04-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  United States    
Other Details:
Languages:  eng     Pagination:  291-302     Citation Subset:  IM    
Department of Neurology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-8897, USA.
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MeSH Terms
Age of Onset
Brain / pathology,  physiopathology*
Diagnosis, Differential
Disease Progression
Efferent Pathways / pathology,  physiopathology*
Genetic Predisposition to Disease / genetics
Motor Neuron Disease / diagnosis*,  physiopathology*
Motor Neurons / pathology*
Pyramidal Tracts / pathology,  physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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