| Primary lateral sclerosis: Predicting functional outcome. | |
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MedLine Citation:
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PMID: 22957717 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Our objective was to investigate functional outcome in primary lateral sclerosis (PLS). We followed a group of 24 patients with PLS. Clinical (ALSFRS), respiratory, and neurophysiological (electromyography and transcranial magnetic stimulation) evaluations were performed at entry and regularly over the follow-up period. The time taken for a greater than 10% decrease in ALSFRS compared to the first assessment was defined as the dichotomous outcome; prognostic factors were evaluated using the Cox proportional hazard model. Results demonstrated that the median age at symptom onset was 54 years (range 28-75 years). In 46% symptoms began in the lower limbs, in 21% in the upper limbs and in 33% in bulbar muscles. The median symptom duration at first visit was 3.1 years (range 0.9-11.7 years). At last follow-up the median disease duration was 9.9 years (range 4.2-17.6 years). The median follow-up time was 4.6 years (range 2.1-11 years). We excluded from final analysis three patients with positive family history. Older age at onset (p = 0.019) was related to more rapid functional impairment; gender, forced vital capacity, region of onset and neurophysiological changes did not predict outcome. In conclusion, age is the most critical prognostic factor for functional outcome in PLS. |
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Authors:
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Vânia Almeida; Mamede de Carvalho; Manuel Scotto; Susana Pinto; Anabela Pinto; Benjamim Ohana; Michael Swash |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-8 |
Journal Detail:
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Title: Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases Volume: - ISSN: 1471-180X ISO Abbreviation: Amyotroph Lateral Scler Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101283386 Medline TA: Amyotroph Lateral Scler Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Neurosciences, Hospital de Santa Maria-CHLN , Lisbon. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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