Document Detail


Primary laryngeal lymphoma: report of 3 cases and review of the literature.
MedLine Citation:
PMID:  19378323     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Extranodal lymphomas limited to the larynx are rare, accounting for less than 1% of all laryngeal neoplasms. The aim of this study was to report the experience of our department in the management of these aggressive lesions, as they require special diagnostic and therapeutic attention. METHODS: The case records of 3 patients with the diagnosis of lymphoma involving the larynx were retrospectively reviewed. RESULTS: The histopathological diagnosis revealed 1 case of marginal zone lymphoma mucosa-associated lymphoid tissue type, 1 case of T-lymphoblastic lymphoma, and 1 case of a rare coexistence of in situ squamous cell carcinoma with an isolated intravascular (angioimmunoblastic) lymphoma of peripheral T-cell origin. Details of the presentation, diagnostic procedures, treatment, and outcome of these patients were presented. CONCLUSIONS: Primary laryngeal lymphoma is a rare entity. Early symptoms are subtle and nonspecific, and confirmation of the diagnosis is often difficult. Because of the rarity of this tumor type, the optimal management remains controversial and it seems that should be managed not as a distinct disease entity but as an unusual presentation of non-Hodgkin lymphoma, according to the recent treatment trends.
Authors:
Konstantinos Markou; John Goudakos; John Constantinidis; Ioannis Kostopoulos; Victor Vital; Angelos Nikolaou
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Head & neck     Volume:  32     ISSN:  1097-0347     ISO Abbreviation:  Head Neck     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-17     Completed Date:  2010-06-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8902541     Medline TA:  Head Neck     Country:  United States    
Other Details:
Languages:  eng     Pagination:  541-9     Citation Subset:  IM    
Affiliation:
Department of Otorhinolaryngology-Head and Neck Surgery, ENT Department, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Biopsy, Needle
Combined Modality Therapy
Fatal Outcome
Humans
Immunohistochemistry
Laryngeal Neoplasms / diagnosis,  pathology*,  therapy
Lymphoma, B-Cell, Marginal Zone / diagnosis,  pathology*,  therapy
Lymphoma, Non-Hodgkin / diagnosis,  pathology*,  therapy
Male
Middle Aged
Neoplasm Staging
Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis,  pathology*,  therapy
Prognosis
Radiotherapy, High-Energy / methods
Risk Assessment
Tracheotomy / methods

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