Document Detail

Primary intravascular synovial sarcoma: a disease of young adult women? Report of a case diagnosed by aspiration biopsy and review of the literature.
MedLine Citation:
PMID:  17183757     Owner:  NLM     Status:  MEDLINE    
Intravascular synovial sarcoma (IVSS) is an extremely rare tumor with only four well-documented cases in the English literature. All tumors were located in large veins of the lower extremities or trunk in young women except for one case occurring in a 54-yr-old woman. We report here an additional case of IVSS arising from the superior vena cava in a 32-yr-old woman who presented with a cervical mass and superior vena cava syndrome. A fine-needle aspiration biopsy (FNAB) was performed and showed a malignant biphasic tumor with spindle cell and epithelioid components. The tumor cells were negative for CD31, CD34, factor VIII, desmin, smooth muscle actin, and S-100 protein, and had positive staining for vimentin and cytokeratin (AE1/AE3) predominantly in the spindle and epithelial components, respectively. A diagnosis of synovial sarcoma was made and confirmed in a subsequent transvascular biopsy demonstrating chromosomal translocation t(X, 18) by fluorescence in situ hybridization using a dual color, break-apart-style probe for SYT. Although clinically similar to previously reported IVSS, this is the first case arising in large veins of the upper portion of the trunk and diagnosed by FNAB.
Guo-Xia Tong; John R Goldblum; Wansong Qiu; Marek Skacel; Erinn Downs-Kelly; Sohail Contractor; Pascale Levine
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Diagnostic cytopathology     Volume:  34     ISSN:  8755-1039     ISO Abbreviation:  Diagn. Cytopathol.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-21     Completed Date:  2007-01-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8506895     Medline TA:  Diagn Cytopathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  834-8     Citation Subset:  IM    
Copyright Information:
(c) 2006 Wiley-Liss, Inc.
Department of Pathology, Columbia University Medical Center, New York, NY, USA.
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MeSH Terms
Age Factors
Biopsy, Fine-Needle
Diagnosis, Differential
Sarcoma, Synovial / diagnosis*,  genetics,  pathology
Sex Factors
Translocation, Genetic
Vascular Neoplasms / diagnosis*,  genetics,  pathology

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