| Primary intraepithelial sebaceous gland carcinoma of the palpebral conjunctiva. | |
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MedLine Citation:
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PMID: 11346408 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sebaceous gland carcinoma usually arises from meibomian or Zeis glands deep within the eyelid, but it can rarely arise within the conjunctival epithelium without a deep component. We describe a woman with a history of chronic blepharoconjunctivitis unresponsive to topical medications. Examination disclosed confluent papillary hypertrophy of the upper palpebral conjunctiva and deposits of white flaky material. Tarsoconjunctival punch biopsy revealed intraepithelial sebaceous gland carcinoma. Management consisted of frozen section-controlled complete tumor excision with removal of the entire posterior lamella of the right upper eyelid, cryotherapy to the margins, and reconstruction. Histopathologic analysis confirmed primary sebaceous gland carcinoma localized to the conjunctival epithelium without involvement of underlying meibomian or Zeis glands or the caruncle. Patients with unexplained chronic unilateral blepharoconjunctivitis or papillary hypertrophy of the palpebral conjunctiva should be considered for biopsy to rule out neoplasia, even when there is no sign of an underlying eyelid mass. |
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Authors:
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S G Honavar; C L Shields; M Maus; J A Shields; H Demirci; R C Eagle |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of ophthalmology Volume: 119 ISSN: 0003-9950 ISO Abbreviation: Arch. Ophthalmol. Publication Date: 2001 May |
Date Detail:
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Created Date: 2001-05-10 Completed Date: 2001-05-21 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7706534 Medline TA: Arch Ophthalmol Country: United States |
Other Details:
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Languages: eng Pagination: 764-7 Citation Subset: AIM; IM |
Affiliation:
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Oncology Service, Wills Eye Hospital, Philadelphia, PA 19107, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Apolipoproteins* Apolipoproteins D Biological Markers Carcinoma in Situ / chemistry, pathology*, surgery Carrier Proteins / analysis Conjunctival Neoplasms / chemistry, pathology*, surgery Female Glycoproteins* Humans Keratins / analysis Membrane Transport Proteins* Mucin-1 / analysis Neoplasm Proteins / analysis Sebaceous Gland Neoplasms / chemistry, pathology*, surgery Tumor Markers, Biological / analysis |
| Chemical | |
Reg. No./Substance:
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0/APOD protein, human; 0/Apolipoproteins; 0/Apolipoproteins D; 0/Biological Markers; 0/CAM 5.2 antigen; 0/Carrier Proteins; 0/Glycoproteins; 0/Membrane Transport Proteins; 0/Mucin-1; 0/Neoplasm Proteins; 0/Tumor Markers, Biological; 68238-35-7/Keratins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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