| Primary intracranial leiomyosarcoma in an HIV-infected patient. | |
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MedLine Citation:
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PMID: 20676716 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Primary intracranial leiomyosarcomas are rare tumors arising from the mesenchymal cells of the dura matter or the cerebral blood vessels. Only 14 cases of primary intracranial leiomyosarcoma are reported in the literature. We report a case of primary intracranial leiomyosarcoma in an human immunodeficiency virus-positive patient with a CD4 count of 14 cells/μL. Additionally, in-situ hybridization of Epstein-Barr virus (EBV) early RNA stained sections highlighted the tumor cells, consistent with the presence of EBV. Review of the literature strongly suggests an association between AIDS, EBV, and primary intracranial leiomyosarcoma. Given the paucity of information in the literature, we review possible chemotherapeutic agents for treatment of primary intracranial leiomyosarcoma in patients refractory to surgical resection and radiation therapy. |
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Authors:
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Shanthi Sivendran; Claudia Irene Vidal; Myra F Barginear |
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Publication Detail:
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Type: Case Reports; Journal Article; Review Date: 2010-07-30 |
Journal Detail:
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Title: International journal of clinical oncology / Japan Society of Clinical Oncology Volume: 16 ISSN: 1437-7772 ISO Abbreviation: Int. J. Clin. Oncol. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-10 Completed Date: 2011-05-24 Revised Date: 2011-09-13 |
Medline Journal Info:
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Nlm Unique ID: 9616295 Medline TA: Int J Clin Oncol Country: Japan |
Other Details:
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Languages: eng Pagination: 63-6 Citation Subset: IM |
Affiliation:
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Tisch Cancer Institute, The Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1079, New York, NY 10029, USA, shanthi.sivendran@mssm.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acquired Immunodeficiency Syndrome
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complications*,
drug therapy Adult Anti-Retroviral Agents / therapeutic use Brain Neoplasms / pathology*, surgery, virology* Epstein-Barr Virus Infections / drug therapy, pathology*, virology* Herpesvirus 4, Human / isolation & purification* Humans Leiomyosarcoma / pathology*, surgery, virology* Magnetic Resonance Imaging Male |
| Chemical | |
Reg. No./Substance:
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0/Anti-Retroviral Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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