Document Detail

Primary intracranial leiomyosarcoma in an HIV-infected patient.
MedLine Citation:
PMID:  20676716     Owner:  NLM     Status:  MEDLINE    
Primary intracranial leiomyosarcomas are rare tumors arising from the mesenchymal cells of the dura matter or the cerebral blood vessels. Only 14 cases of primary intracranial leiomyosarcoma are reported in the literature. We report a case of primary intracranial leiomyosarcoma in an human immunodeficiency virus-positive patient with a CD4 count of 14 cells/μL. Additionally, in-situ hybridization of Epstein-Barr virus (EBV) early RNA stained sections highlighted the tumor cells, consistent with the presence of EBV. Review of the literature strongly suggests an association between AIDS, EBV, and primary intracranial leiomyosarcoma. Given the paucity of information in the literature, we review possible chemotherapeutic agents for treatment of primary intracranial leiomyosarcoma in patients refractory to surgical resection and radiation therapy.
Shanthi Sivendran; Claudia Irene Vidal; Myra F Barginear
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2010-07-30
Journal Detail:
Title:  International journal of clinical oncology     Volume:  16     ISSN:  1437-7772     ISO Abbreviation:  Int. J. Clin. Oncol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-10     Completed Date:  2011-05-24     Revised Date:  2012-12-13    
Medline Journal Info:
Nlm Unique ID:  9616295     Medline TA:  Int J Clin Oncol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  63-6     Citation Subset:  IM    
Tisch Cancer Institute, The Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1079, New York, NY 10029, USA,
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MeSH Terms
Acquired Immunodeficiency Syndrome / complications*,  drug therapy
Anti-Retroviral Agents / therapeutic use
Brain Neoplasms / pathology*,  surgery,  virology*
Epstein-Barr Virus Infections / drug therapy,  pathology*,  virology*
Herpesvirus 4, Human / isolation & purification*
Leiomyosarcoma / pathology*,  surgery,  virology*
Magnetic Resonance Imaging
Reg. No./Substance:
0/Anti-Retroviral Agents

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