Document Detail


Primary intracerebral lymphoma in systemic lupus erythematosus treated with immunosuppressives.
MedLine Citation:
PMID:  2673604     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 38-year-old woman suffering from systemic lupus erythematosus was treated with cyclophosphamide and prednisone. Two months later she developed mononeuritis multiplex. After one year, she showed a personality change with aggressiveness and paranoid delusions. Grand mal epileptic fits began to occur. An unenhanced CT-scan showed extensive and bilateral frontal hypodense lesions originally ascribed to vasculitis-caused infarcts. On autopsy, a primary intracerebral lymphoma with extensive necroses was demonstrated. The relationship between SLE, immunosuppressive treatment and primary intracerebral lymphoma is discussed.
Authors:
P Cras; C Franckx; J J Martin
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Clinical neuropathology     Volume:  8     ISSN:  0722-5091     ISO Abbreviation:  Clin. Neuropathol.     Publication Date:    1989 Jul-Aug
Date Detail:
Created Date:  1989-10-19     Completed Date:  1989-10-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8214420     Medline TA:  Clin Neuropathol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  200-5     Citation Subset:  IM    
Affiliation:
Laboratory of Neuropathology, Born-Bunge Foundation, University of Antwerp, Wilrijk, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Adult
Brain Neoplasms / etiology*,  pathology,  radiography
Cyclophosphamide / therapeutic use*
Drug Therapy, Combination
Female
Humans
Lupus Erythematosus, Systemic / complications*,  drug therapy
Lymphoma / etiology*,  pathology,  radiography
Methylprednisolone / therapeutic use*
Necrosis
Tomography, X-Ray Computed
Chemical
Reg. No./Substance:
50-18-0/Cyclophosphamide; 83-43-2/Methylprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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