Document Detail


Primary insulin insufficiency after blocking of zinc in pancreatic beta-cells.
MedLine Citation:
PMID:  7021128     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Diabetogenic effects of various analogues of 8-aminoquinoline were studied. Out of 10 compounds investigated only three showed diabetogenic properties: 8-(p-tolylsulfonylamino)-quinoline, 8-(p-benzenesulfonylamino)-quinoline and 8-(p-methylsulfonylamino)-quinoline. After the injection of these compounds a long term persistent hyperglycemia took place in rabbits and also degenerative changes of insulin producing cells in pancreatic islets were found. All above compounds form stable complexes with zinc in beta-cells and their diabetogenic action diminished together with their ability to form such complexes. Thus, it may be assumed that a formation of these complexes may be one of possible mechanisms of primary insulin insufficiency.
Authors:
J A Lazaris; Z E Bavelskyi
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Endocrinologia experimentalis     Volume:  15     ISSN:  0013-7200     ISO Abbreviation:  Endocrinol. Exp.     Publication Date:  1981  
Date Detail:
Created Date:  1981-10-14     Completed Date:  1981-10-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0125712     Medline TA:  Endocrinol Exp     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  99-109     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aminoquinolines / pharmacology*
Animals
Diabetes Mellitus / chemically induced
Female
Insulin / biosynthesis*,  deficiency*
Islets of Langerhans / drug effects*,  metabolism,  ultrastructure
Kinetics
Male
Rabbits
Tosyl Compounds*
Zinc / antagonists & inhibitors*
Chemical
Reg. No./Substance:
0/Aminoquinolines; 0/Tosyl Compounds; 10304-39-9/8-(4-tolylsulfonylamino)quinoline; 10374-76-2/8-(methylsulfonylamino)quinoline; 11061-68-0/Insulin; 16082-59-0/8-(4-benzenesulfonylamino)quinoline; 7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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