| Primary insulin insufficiency after blocking of zinc in pancreatic beta-cells. | |
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MedLine Citation:
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PMID: 7021128 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Diabetogenic effects of various analogues of 8-aminoquinoline were studied. Out of 10 compounds investigated only three showed diabetogenic properties: 8-(p-tolylsulfonylamino)-quinoline, 8-(p-benzenesulfonylamino)-quinoline and 8-(p-methylsulfonylamino)-quinoline. After the injection of these compounds a long term persistent hyperglycemia took place in rabbits and also degenerative changes of insulin producing cells in pancreatic islets were found. All above compounds form stable complexes with zinc in beta-cells and their diabetogenic action diminished together with their ability to form such complexes. Thus, it may be assumed that a formation of these complexes may be one of possible mechanisms of primary insulin insufficiency. |
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Authors:
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J A Lazaris; Z E Bavelskyi |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Endocrinologia experimentalis Volume: 15 ISSN: 0013-7200 ISO Abbreviation: Endocrinol. Exp. Publication Date: 1981 |
Date Detail:
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Created Date: 1981-10-14 Completed Date: 1981-10-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0125712 Medline TA: Endocrinol Exp Country: CZECHOSLOVAKIA |
Other Details:
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Languages: eng Pagination: 99-109 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aminoquinolines
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pharmacology* Animals Diabetes Mellitus / chemically induced Female Insulin / biosynthesis*, deficiency* Islets of Langerhans / drug effects*, metabolism, ultrastructure Kinetics Male Rabbits Tosyl Compounds* Zinc / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
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0/Aminoquinolines; 0/Tosyl Compounds; 10304-39-9/8-(4-tolylsulfonylamino)quinoline; 10374-76-2/8-(methylsulfonylamino)quinoline; 11061-68-0/Insulin; 16082-59-0/8-(4-benzenesulfonylamino)quinoline; 7440-66-6/Zinc |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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