| Primary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee. | |
| | |
MedLine Citation:
|
PMID: 17952897 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Primary immunodeficiency diseases (PIDs) are a genetically heterogeneous group of disorders that affect distinct components of the innate and adaptive immune system, such as neutrophils, macrophages, dendritic cells, complement proteins, natural killer cells, and T and B lymphocytes. The study of these diseases has provided essential insights into the functioning of the immune system. More than 120 distinct genes have been identified, whose abnormalities account for more than 150 different forms of PID. The complexity of the genetic,immunologic, and clinical features of PID has prompted the need for their classification, with the ultimate goal of facilitating diagnosis and treatment. To serve this goal, an international committee of experts has met every 2 years since 1970. In its last meeting in Jackson Hole, Wyo, after 3 days of intense scientific presentations and discussions, the committee has updated the classification of PID, as reported in this article. |
| | |
Authors:
|
Raif S Geha; Luigi D Notarangelo; Jean-Laurent Casanova; Helen Chapel; Mary Ellen Conley; Alain Fischer; Lennart Hammarström; Shigeaki Nonoyama; Hans D Ochs; Jennifer M Puck; Chaim Roifman; Reinhard Seger; Josiah Wedgwood; |
Related Documents
:
|
21573737 - Td-12 workshop report: characterization of monoclonal antibodies to neuron-specific eno... 21658007 - Trali - new challenges for histocompatibility and immunogenetics in transfusion medicine. 19399547 - Autoimmune autonomic ganglionopathy: treatment by plasma exchanges and rituximab. 18605087 - Detection of human antibodies generated against therapeutic antibodies used in tumor th... 7512157 - Native oligomeric human immunodeficiency virus type 1 envelope glycoprotein elicits div... 8844607 - Protective immunity induced with the antigens fractionated by affinity chromatography f... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Journal of allergy and clinical immunology Volume: 120 ISSN: 0091-6749 ISO Abbreviation: J. Allergy Clin. Immunol. Publication Date: 2007 Oct |
Date Detail:
|
Created Date: 2007-10-19 Completed Date: 2007-11-02 Revised Date: 2011-09-26 |
Medline Journal Info:
|
Nlm Unique ID: 1275002 Medline TA: J Allergy Clin Immunol Country: United States |
Other Details:
|
Languages: eng Pagination: 776-94 Citation Subset: AIM; IM |
Affiliation:
|
Division of Immunology, Children's Hospital, Boston, MA 02115, USA. faif.geha@childrens.harvard.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Humans Immune System / physiology Immunologic Deficiency Syndromes / classification*, genetics, immunology |
| Grant Support | |
ID/Acronym/Agency:
|
AI-35714/AI/NIAID NIH HHS; P01 AI035714-100005/AI/NIAID NIH HHS; R13 AI066891-01/AI/NIAID NIH HHS; R13 AI066891-02/AI/NIAID NIH HHS; R13 AI066891-03/AI/NIAID NIH HHS; R13 AI066891-04/AI/NIAID NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Classification of vegetable oils according to their botanical origin using amino acid profiles estab...
Next Document: Subcutaneous open-loop insulin delivery for type 1 diabetes: Paradigm Real-Time System.