| Primary immunodeficiencies: 2009 update. | |
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MedLine Citation:
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PMID: 20004777 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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More than 50 years after Ogdeon Bruton's discovery of congenital agammaglobulinemia, human primary immunodeficiencies (PIDs) continue to unravel novel molecular and cellular mechanisms that govern development and function of the human immune system. This report provides the updated classification of PIDs that has been compiled by the International Union of Immunological Societies Expert Committee on Primary Immunodeficiencies after its biannual meeting in Dublin, Ireland, in June 2009. Since the appearance of the last classification in 2007, novel forms of PID have been discovered, and additional pathophysiology mechanisms that account for PID in human beings have been unraveled. Careful analysis and prompt recognition of these disorders is essential to prompt effective forms of treatment and thus to improve survival and quality of life in patients affected with PIDs. |
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Authors:
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; Luigi D Notarangelo; Alain Fischer; Raif S Geha; Jean-Laurent Casanova; Helen Chapel; Mary Ellen Conley; Charlotte Cunningham-Rundles; Amos Etzioni; Lennart Hammartröm; Shigeaki Nonoyama; Hans D Ochs; Jennifer Puck; Chaim Roifman; Reinhard Seger; Josiah Wedgwood |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of allergy and clinical immunology Volume: 124 ISSN: 1097-6825 ISO Abbreviation: J. Allergy Clin. Immunol. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-16 Completed Date: 2010-01-12 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 1275002 Medline TA: J Allergy Clin Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 1161-78 Citation Subset: AIM; IM |
Affiliation:
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Division of Immunology, Children's Hospital Boston and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. luigi.notarangelo@childrens.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Autoimmunity
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immunology B-Lymphocytes / immunology, metabolism Complement System Proteins / immunology*, metabolism Cytokines / immunology, metabolism Humans Immunity, Innate Immunoglobulins / blood Immunologic Deficiency Syndromes / classification*, immunology*, therapy Killer Cells, Natural / immunology, metabolism T-Lymphocytes / immunology, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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AI-35714/AI/NIAID NIH HHS; P01 AI035714-100005/AI/NIAID NIH HHS; R13 AI066891-05/AI/NIAID NIH HHS; R13-AI-066891/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Immunoglobulins; 9007-36-7/Complement System Proteins |
| Comments/Corrections | |
Erratum In:
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J Allergy Clin Immunol. 2010 Mar;125(3):771-3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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