| Primary hyperparathyroidism in patients with multiple endocrine neoplasia type 1: comparison with sporadic parathyroid adenomas. | |
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MedLine Citation:
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PMID: 11544565 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A prospective study on the natural course of primary hyperparathyroidism has recently been reported. Since hyperparathyroidism in multiple endocrine neoplasia type 1 (MEN 1) is genetically distinct from most forms of sporadic hyperparathyroidism, it is important to know the natural course of hyperparathyroidism in MEN 1 for better clinical management. For this purpose, we retrospectively reviewed clinical parameters of patients with MEN 1 when they were diagnosed as having hyperparathyroidism, and compared them with those of patients with sporadic primary hyperparathyroidism. In patients with MEN 1: 1) levels of intact PTH (i-PTH) gradually increased with age, which accelerated over 40 years; 2) compared to the steep rise in i-PTH levels in aged patients, increase in serum calcium or decrease of serum inorganic phosphate concentration was relatively mild, and 3) the high concentrations of i-PTH in aged patients were not due to renal insufficiency. These features were not observed in patients with sporadic primary parathyroid adenomas. Clinical features of untreated hyperparathyroidism in MEN 1 may be significantly affected by the age of the patient. The effect, if any, of age-dependent deterioration on recurrence rate after subtotal or total parathyroidectomy requires further elucidation. |
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Authors:
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M Katai; A Sakurai; Y Ikeo; K Hashizume |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme Volume: 33 ISSN: 0018-5043 ISO Abbreviation: Horm. Metab. Res. Publication Date: 2001 Aug |
Date Detail:
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Created Date: 2001-09-06 Completed Date: 2001-12-05 Revised Date: 2009-02-19 |
Medline Journal Info:
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Nlm Unique ID: 0177722 Medline TA: Horm Metab Res Country: Germany |
Other Details:
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Languages: eng Pagination: 499-503 Citation Subset: IM |
Affiliation:
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Department of Aging Medicine and Geriatrics, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621 Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma
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blood Adolescent Adult Aged Aged, 80 and over Aging / blood* Calcium / blood Female Humans Hyperparathyroidism / blood*, complications, pathology Kidney Failure / blood Male Middle Aged Multiple Endocrine Neoplasia Type 1 / blood*, complications, genetics Organ Size Parathyroid Glands / pathology Parathyroid Hormone / blood* Parathyroid Neoplasms / blood*, pathology Phosphates / blood Regression Analysis Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Parathyroid Hormone; 0/Phosphates; 7440-70-2/Calcium |
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