Document Detail

Primary hyperparathyroidism in patients with multiple endocrine neoplasia type 1: comparison with sporadic parathyroid adenomas.
MedLine Citation:
PMID:  11544565     Owner:  NLM     Status:  MEDLINE    
A prospective study on the natural course of primary hyperparathyroidism has recently been reported. Since hyperparathyroidism in multiple endocrine neoplasia type 1 (MEN 1) is genetically distinct from most forms of sporadic hyperparathyroidism, it is important to know the natural course of hyperparathyroidism in MEN 1 for better clinical management. For this purpose, we retrospectively reviewed clinical parameters of patients with MEN 1 when they were diagnosed as having hyperparathyroidism, and compared them with those of patients with sporadic primary hyperparathyroidism. In patients with MEN 1: 1) levels of intact PTH (i-PTH) gradually increased with age, which accelerated over 40 years; 2) compared to the steep rise in i-PTH levels in aged patients, increase in serum calcium or decrease of serum inorganic phosphate concentration was relatively mild, and 3) the high concentrations of i-PTH in aged patients were not due to renal insufficiency. These features were not observed in patients with sporadic primary parathyroid adenomas. Clinical features of untreated hyperparathyroidism in MEN 1 may be significantly affected by the age of the patient. The effect, if any, of age-dependent deterioration on recurrence rate after subtotal or total parathyroidectomy requires further elucidation.
M Katai; A Sakurai; Y Ikeo; K Hashizume
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme     Volume:  33     ISSN:  0018-5043     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-09-06     Completed Date:  2001-12-05     Revised Date:  2009-02-19    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  499-503     Citation Subset:  IM    
Department of Aging Medicine and Geriatrics, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621 Japan.
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MeSH Terms
Adenoma / blood
Aged, 80 and over
Aging / blood*
Calcium / blood
Hyperparathyroidism / blood*,  complications,  pathology
Kidney Failure / blood
Middle Aged
Multiple Endocrine Neoplasia Type 1 / blood*,  complications,  genetics
Organ Size
Parathyroid Glands / pathology
Parathyroid Hormone / blood*
Parathyroid Neoplasms / blood*,  pathology
Phosphates / blood
Regression Analysis
Retrospective Studies
Reg. No./Substance:
0/Parathyroid Hormone; 0/Phosphates; 7440-70-2/Calcium

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