Document Detail

Primary hyperoxaluria type 1 in Japan.
MedLine Citation:
PMID:  11330044     Owner:  NLM     Status:  MEDLINE    
Glyoxylate is an immediate precursor of oxalate, but in its metabolism the conversion into glycine catalyzed by serine:pyruvate/alanine:glyoxylate aminotransferase (SPT/AGT) appears to be the main route. When SPT/AGT is missing as in the case of primary hyperoxaluria type 1 (PH1) more glyoxylate is used for the oxalate production, resulting in calcium oxalate urolithiasis and finally systemic oxalosis. SPT/AGT is a unique enzyme of species-specific dual organelle localization; it is located largely in mitochondria in carnivores and entirely in peroxisomes in herbivores and man. For herbivores, the peroxisomal localization of SPT/AGT is indispensable to avoid massive production of oxalate, probably because liver peroxisomes are the main site of glyoxylate production from glycolate, and plants contain glycolate much more than animal tissues. Recently, we took charge of laboratory examination for 8 cases of primary hyperoxaluria in Japan, and felt that symptoms of some of the Japanese PH1 patients are apparently milder than those of Western patients. The reason of this is not clear, but from the above mentioned seemingly indispensable association of grass-eating with the peroxisomal localization of SPT/AGT it may be related, at least in part, to the food habit of Japanese, especially that of old generation, that they prefer boiled greens rather than frying or raw vegetables.
A Ichiyama; T Oda; E Maeda-Nakai
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cell biochemistry and biophysics     Volume:  32 Spring     ISSN:  1085-9195     ISO Abbreviation:  Cell Biochem. Biophys.     Publication Date:  2000  
Date Detail:
Created Date:  2001-05-01     Completed Date:  2001-06-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9701934     Medline TA:  Cell Biochem Biophys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  171-6     Citation Subset:  IM    
First Department of Biochemistry, Hamamatsu University School of Medicine, 3600 Handa-cho, Hamamatsu, Shizuoka 431-3192, Japan.
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MeSH Terms
Hyperoxaluria / epidemiology,  metabolism*,  physiopathology
Japan / epidemiology
Oxalates / metabolism*
Transaminases / metabolism
Reg. No./Substance:
0/Oxalates; EC 2.6.1.-/Transaminases; EC 2.6.1.-/glyoxylate aminotransferase

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