| Primary human hepatocyte transplantation in the therapy of hepatic failure: 2 cases report. | |
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MedLine Citation:
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PMID: 22221764 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Liver failure is the end stage of hepatopathy with unfavorable prognosis. In two patients with liver failure, viable primary human hepatocytes, obtained from resected liver tissue of patients with hepatolithiasis, were transplanted into the spleen by interventional therapy through femoral arterial cannula. After transplantation, the patients' clinical symptoms and liver function were significantly improved. However, their bilirubin increased within six days following transplantation. One suffered from hepatic coma and give up treatment and the other patient died forteen days after transplantation. It is technically safe to treat liver failure by intrasplenic transplantation of adult hepatocytes and the clinical efficacy has been confirmed. How to make transplanted hepatic cells proliferate and functionally survive is the key point to maintain continuous improvement of the recipient's hepatic function. |
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Authors:
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Zhuo-Ri Li; Xian-Hai Mao; Xiao-Xuan Hu; Sheng-Dan Nie; Yong-Zhong Shi; Hua Xiang; Jian-Hui Yang; Ou-De Cao |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Asian Pacific journal of tropical medicine Volume: 5 ISSN: 1995-7645 ISO Abbreviation: Asian Pac J Trop Med Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101533720 Medline TA: Asian Pac J Trop Med Country: Singapore |
Other Details:
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Languages: eng Pagination: 165-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Hainan Medical College. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Hepatobiliary Surgery, Hainan Provincial People's Hospital, Haikou 570311, Hainan, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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