Document Detail

Primary hepatosplenic large B-cell lymphoma: a rare aggressive tumor.
MedLine Citation:
PMID:  21490848     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Diffuse large B-cell lymphoma is the most common form of lymphoma. It usually begins in the lymph nodes; up to 40% may have an extranodal presentation. According to a definition of primary extranodal lymphoma with presentation only in extranodal sites, there are reports of large B-cell lymphomas limited to liver or spleen as separate entities, and to date there have been only three documented cases of primary hepatosplenic presentation. This paper reports a fourth case. Due to a review of the literature and the clinical course of the case reported, we conclude that primary hepatosplenic large B-cell lymphoma has been found predominantly in females older than 60 years. The patients reported had <2 months of evolution prior to diagnosis, prominent B symptoms, splenomegaly in three and hepatomegaly in two, none with lymph node involvement. All had thrombocytopenia and abnormal liver function tests; three had anemia and elevated serum lactic dehydrogenase levels, two with hemophagocytosis in bone marrow. Because of the previously mentioned data, it can be stated that primary hepatosplenic lymphoma is an uncommon and aggressive form of disease that requires immediate recognition and treatment.
M R Morales-Polanco; R Drijansky-Morgenstern; E Murillo-Meza; E Gómez-Morales
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Publication Detail:
Type:  Journal Article     Date:  2008-03-13
Journal Detail:
Title:  Case reports in gastroenterology     Volume:  2     ISSN:  1662-0631     ISO Abbreviation:  Case Rep Gastroenterol     Publication Date:  2008  
Date Detail:
Created Date:  2011-04-14     Completed Date:  2012-10-02     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101474819     Medline TA:  Case Rep Gastroenterol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  109-15     Citation Subset:  -    
Hematology, ABC Medical Center, Mexico City, Mexico.
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