Document Detail


Primary gonadal damage following treatment of brain tumors in childhood.
MedLine Citation:
PMID:  6620016     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gonadal function was studied in two groups of children previously treated for medulloblastoma with surgery followed by postoperative craniospinal irradiation. In group 1 but not in group 2, the children also received adjuvant chemotherapy for one to two years. All children in group 1 received a nitrosourea (BCNU or CCNU), plus vincristine in four and procarbazine in three patients. The nine children in group 1 showed clinical and biochemical evidence of gonadal damage with elevated serum FSH concentrations and, in the boys, small testes for their stage of pubertal development. In group 2 (n = 8), each child had completed pubertal development normally, the boys had adult sized testes and the girls regular menses. Gonadotropin values were normal in all eight children. We conclude that nitrosoureas were responsible for the gonadal damage in the children in group 1, with procarbazine also contributing to the damage in the three children who received this drug. In view of the limited proved value of adjuvant chemotherapy with nitrosoureas in the treatment of medulloblastoma, recognition of this serious complication of cytotoxic drug therapy may necessitate reassessing in which subgroups of children with medulloblastoma the benefits of adjuvant chemotherapy outweight the complications.
Authors:
S R Ahmed; S M Shalet; R H Campbell; D P Deakin
Related Documents :
11365846 - Antivirals and children.
9183126 - Pharmacology of the selective serotonin reuptake inhibitors in children and adolescents.
11185396 - Clinical trials. planned ritalin trial for tots heads into uncharted waters.
12186136 - Posterior leukoencephalopathy in a girl with acute haemorrhagic leukoencephalitis.
19871096 - The interaction of host and bacterium in the development of communicability by streptoc...
1424376 - Pulmonary scintigraphic findings in children with pectus excavatum by the comparison of...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  103     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1983 Oct 
Date Detail:
Created Date:  1983-11-23     Completed Date:  1983-11-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  562-5     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Antineoplastic Combined Chemotherapy Protocols / adverse effects
Cerebellar Neoplasms / physiopathology,  radiotherapy*,  surgery
Child
Child, Preschool
Combined Modality Therapy / adverse effects
Female
Humans
Male
Medulloblastoma / physiopathology,  radiotherapy*,  surgery
Ovary / drug effects,  radiation effects*
Postoperative Care
Puberty / drug effects,  radiation effects
Radiation Injuries / physiopathology*
Testis / drug effects,  radiation effects*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Brain metastases in children.
Next Document:  Needle muscle biopsy in infants and children.