Document Detail

Primary gonadal damage following treatment of brain tumors in childhood.
MedLine Citation:
PMID:  6620016     Owner:  NLM     Status:  MEDLINE    
Gonadal function was studied in two groups of children previously treated for medulloblastoma with surgery followed by postoperative craniospinal irradiation. In group 1 but not in group 2, the children also received adjuvant chemotherapy for one to two years. All children in group 1 received a nitrosourea (BCNU or CCNU), plus vincristine in four and procarbazine in three patients. The nine children in group 1 showed clinical and biochemical evidence of gonadal damage with elevated serum FSH concentrations and, in the boys, small testes for their stage of pubertal development. In group 2 (n = 8), each child had completed pubertal development normally, the boys had adult sized testes and the girls regular menses. Gonadotropin values were normal in all eight children. We conclude that nitrosoureas were responsible for the gonadal damage in the children in group 1, with procarbazine also contributing to the damage in the three children who received this drug. In view of the limited proved value of adjuvant chemotherapy with nitrosoureas in the treatment of medulloblastoma, recognition of this serious complication of cytotoxic drug therapy may necessitate reassessing in which subgroups of children with medulloblastoma the benefits of adjuvant chemotherapy outweight the complications.
S R Ahmed; S M Shalet; R H Campbell; D P Deakin
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  103     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1983 Oct 
Date Detail:
Created Date:  1983-11-23     Completed Date:  1983-11-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  562-5     Citation Subset:  AIM; IM    
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / adverse effects
Cerebellar Neoplasms / physiopathology,  radiotherapy*,  surgery
Child, Preschool
Combined Modality Therapy / adverse effects
Medulloblastoma / physiopathology,  radiotherapy*,  surgery
Ovary / drug effects,  radiation effects*
Postoperative Care
Puberty / drug effects,  radiation effects
Radiation Injuries / physiopathology*
Testis / drug effects,  radiation effects*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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