Document Detail

Primary gastric choriocarcinoma: a case report and review of the literature.
MedLine Citation:
PMID:  11735700     Owner:  NLM     Status:  MEDLINE    
Choriocarcinoma is a rapidly invasive, widely metastatic human chorionic gonadotropin (HCG)-producing neoplasm, usually intrauterine and gestational. Primary gastric choriocarcinoma is very rare, and its pathogenesis is still uncertain. We report a case of primary gastric choriocarcinoma associated with adenocarcinoma in a 36-year-old woman. The patient presented with gastrointestinal bleeding and a gastric mass clinically suspicious of gastric adenocarcinoma. Histopathologic evaluation proved the tumor to be a choriocarcinoma, with a minor component of a poorly differentiated adenocarcinoma. The patient was treated with a standard nongestational choriocarcinoma chemotherapy regimen. An impressive initial response was evidenced by clinical reduction of the tumor volume and drop of the serum beta-HCG levels after the first cycle. However, the tumor rapidly recurred in the abdomen and disseminated to the lungs, which were documented by new elevation of serum beta-HCG levels and computed tomographic scans despite continuing with 3 more cycles of chemotherapy. The patient died 6 months after diagnosis.
Z Liu; J L Mira; J C Cruz-Caudillo
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  125     ISSN:  0003-9985     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-12-12     Completed Date:  2002-01-25     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1601-4     Citation Subset:  AIM; IM    
Department of Pathology, Texas Tech University, Health Science Center, Lubbock, 79430, USA.
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MeSH Terms
Adenocarcinoma / pathology
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Bleomycin / administration & dosage
Choriocarcinoma / blood,  drug therapy,  secondary*
Chorionic Gonadotropin, beta Subunit, Human / blood
Cisplatin / administration & dosage
Diagnosis, Differential
Etoposide / administration & dosage
Fatal Outcome
Gastrointestinal Hemorrhage / etiology,  pathology
Lung Neoplasms / blood,  drug therapy,  secondary*
Neoplasm Recurrence, Local
Salvage Therapy
Stomach Neoplasms / blood,  drug therapy,  pathology*
Tomography, X-Ray Computed
Reg. No./Substance:
0/Chorionic Gonadotropin, beta Subunit, Human; 11056-06-7/Bleomycin; 15663-27-1/Cisplatin; 33419-42-0/Etoposide

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