Document Detail


Primary gastric T-cell lymphoma not associated with human T-lymphotropic virus type I: a case report and review of the literature.
MedLine Citation:
PMID:  12634958     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Primary gastric T-cell lymphoma (PGTL) not associated with human T-lymphotropic virus type I (HTLV-I) is extremely rare and such a case is reported herein. The patient was a 58-year-old Japanese male presenting with submucosal tumor of the stomach identified on endoscopic examination. The lesion was diagnosed as non-Hodgkin's lymphoma by endoscopic biopsy and classified as peripheral T-cell lymphoma, unspecified, due to clonal rearrangement of the T-cell receptor beta (TCR) gene and expression of TCR beta protein in the absence of B-cell genotypes and phenotypes. Unlike previously reported cases of HTLV-I-unassociated PGTL, lymphoma in the current case was characterized histologically as "low grade" and phenotypically as CD4+, TIA-1+, granzyme B+, and CD103-. The lymphoma responded well to chemotherapy and radiation, and the patient was well with no detectable disease 10 months after initiation of therapy. A review of patients with PGTL in the literature revealed a few long-term survivors, and the investigation of therapeutic strategies for PGTL is, therefore, necessary.
Authors:
N Niitsu; H Nakamine; M Kohri; M Hayama; J Tamaru; K Iwabuchi; S Tanabe; R Horie; M Higashihara
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2003-02-13
Journal Detail:
Title:  Annals of hematology     Volume:  82     ISSN:  0939-5555     ISO Abbreviation:  Ann. Hematol.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-13     Completed Date:  2003-05-07     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  9107334     Medline TA:  Ann Hematol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  197-202     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine IV, Kitasato University School of Medicine, Kanagawa, Japan. nniitsu@med.kitasato-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Biopsy
Blotting, Southern
Bone Marrow / pathology
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
Humans
Immunophenotyping
Lymphoma, T-Cell / genetics,  pathology*,  therapy
Male
Middle Aged
Neoplasm Staging
Radiotherapy
Receptors, Antigen, T-Cell, alpha-beta / genetics
Stomach Neoplasms / genetics,  pathology*,  therapy
Chemical
Reg. No./Substance:
0/Receptors, Antigen, T-Cell, alpha-beta

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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