| Primary focal segmental glomerulosclerosis in Egyptian children: a 10-year single-centre experience. | |
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MedLine Citation:
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PMID: 20195645 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Primary focal segmental glomerulosclerosis (FSGS) in children accounts for 7-20% of all cases of idiopathic nephrotic syndrome (NS). To evaluate the clinical course of children with primary FSGS, the records of 72 patients with biopsy-proven FSGS admitted between 1995 and 2008 were retrospectively analysed. Forty-eight patients were male (66.7%). The mean age at presentation was 76.5 +/- 54 (range 12-192) months. The mean duration of follow-up was 76.3 +/- 42 (range 9-156) months. Seventeen patients (23.6%) presented with gross haematuria at initial presentation, 15 (20.8%) presented with hypertension and 10 patients (14%) presented with chronic renal insufficiency (CRI). The initial response to oral prednisolone was steroid resistance in 63 patients (87.5%) and steroid dependence in 4 patients (5%), while 5 patients (6.9%) were biopsied from the start because of atypical presentation. According to pathological classification, there were the tip variant (2%), collapsing variant (6%), perihilar variant (7%) and NOS (not otherwise specified; 85%). At the last clinical visit, 12 patients (16.7%) were in complete remission and 11 (15.3%) had progressed to CRI. Renal survival rates at 5 and 10 years were 93% and 68%, respectively. In conclusion, in this study we had a low percentage of FSGS, and fewer patients presenting with gross haematuria and hypertension compared with previous reports. In addition, the short-term overall renal survival seems to be better in our cohort. |
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Authors:
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Ahmed M El-Refaey; Ashraf Bakr; Ayman Hammad; Atef Elmougy; Fatma El-Houseeny; Ashraf Abdelrahman; Amr Sarhan |
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Publication Detail:
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Type: Journal Article Date: 2010-03-02 |
Journal Detail:
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Title: Pediatric nephrology (Berlin, Germany) Volume: 25 ISSN: 1432-198X ISO Abbreviation: Pediatr. Nephrol. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-05-21 Completed Date: 2010-08-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8708728 Medline TA: Pediatr Nephrol Country: Germany |
Other Details:
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Languages: eng Pagination: 1369-73 Citation Subset: IM |
Affiliation:
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Pediatric Nephrology Unit, Mansoura University Children's Hospital, Mansoura University, Algomhoria Street, Mansoura, Egypt. Arefaey72@mans.edu.eg |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Biopsy Child Child, Preschool Cohort Studies Comorbidity Cyclosporine / therapeutic use Drug Therapy, Combination Egypt / epidemiology Female Glomerulosclerosis, Focal Segmental / drug therapy, epidemiology*, pathology Hematuria / drug therapy, epidemiology*, etiology Humans Hypertension / epidemiology*, etiology, pathology Infant Kidney Failure, Chronic / epidemiology*, pathology Male Methylprednisolone / therapeutic use Renal Insufficiency, Chronic / drug therapy, epidemiology*, pathology Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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59865-13-3/Cyclosporine; 83-43-2/Methylprednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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